This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $816,661.00 to The Regents of the University of California, San Francisco (UCSF) to conduct comprehensive research into the molecular and cellular mechanisms by which abnormal tau protein leads to neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project aims to systematically map the impact of tau pathology on the cellular proteome, including through disruptions...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Illinois provides funding of $1,592,854 to conduct research on the biological mechanisms underlying tau protein misregulation in neurodegenerative disorders like Alzheimer's disease and related dementias. The key objectives of the 2-year project are to: 1) Define how post-translational modifications of tau affect its normal scaffolding functions and contribute to pathological...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Rutgers, The State University will support research into the role of mitochondrial deficits in tauopathy-linked autophagy defects related to Alzheimer's disease. The $431,750 award, spanning June 2025 to May 2027, will investigate how overexpression of the mitochondrial protein MIRO can enhance autophagy and reduce pathological tau accumulation in tauopathy neurons. The research aims to provide...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,147,300.00 to Wayne State University to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis in Alzheimer's disease models. The research aims to understand the early synaptic dysfunction caused by tau pathology, with the goal of identifying molecular targets for intervention before the irreversible loss of synapses and neurons in Alzheimer's...
This Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) provides $717,709 to Weill Medical College of Cornell University to conduct research on the cellular mechanisms underlying the propagation of misfolded tau protein aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The key objectives are to: 1) Determine how amyloid-beta and tau seeding influence tau protein interactomes in human neurons expressing different tau isoforms;...
This federal Project Grant award of $1,055,595 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand how advancing age contributes to the occurrence and progression of Alzheimer's disease (AD). The key objectives are to: 1) determine how increasing endosome formation, the vehicles for endosome trafficking, can decrease tau protein accumulation in neurons, a hallmark of AD pathology; and 2) define how increasing endosome formation influences cognition and...
This National Institute on Aging (NIA) federal Project Grant award (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to study the synergistic relationship between the tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025 and ending December 31, 2029, aims to investigate the mechanisms underlying how tau and TDP-43 pathologies interact to drive more rapid cognitive decline and hippocampal atrophy in AD. The research will...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $419,375 to the University of Florida to investigate the role of the protein tau and its interaction with cellular RNA in the development of neurodegenerative disorders, such as Alzheimer's disease. The research aims to identify specific RNA motifs that may either enhance or inhibit the formation of tau-based biomolecular condensates, which are associated with the toxic accumulation of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,118,700.00 in funding to New York University (NYU) School of Medicine to conduct research on the disruption of endosomal microautophagy (EMI) by pathological tau protein. The research aims to elucidate the role of tau in destabilizing EMI through mitochondrial disruption and reduced availability of key EMI pathway components. Specific objectives include manipulating EMI components to determine their vulnerability to pathological tau, and testing whether normalizing the activity of a key EMI protein, HSC70, can rescue tau-induced dysfunction in EMI and neuronal signaling. The 2-year award period runs from August 1, 2024 to April 30, 2026. The findings could provide important insights into the mechanisms underlying Alzheimer's disease and identify potential targets for future interventions.