Project Grant R21AA032427
- The National Institute on Alcohol Abuse and Alcoholism awarded The Research Foundation for the State University of New York $2.12 million on August 4, 2026, under the Alcohol Research Programs (CFDA 93.273) to support research into neurobiological factors contributing to tolerance to the adverse consequences of alcohol. The research examines how individuals vary in their sensitivity to the aversive effects of alcohol and how tolerance to these effects develops following repeated alcohol...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $700,134 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a longitudinal study tracking the development of alcohol tolerance from the onset of regular drinking in young adults. The research will recruit 300 eighteen- to nineteen-year-olds who drink at low-risk levels and show no DSM-related tolerance symptoms, oversampled for risk factors associated with problematic alcohol...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Tufts College $686,774 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct behavioral neurobiology research on stress, alcohol responsivity, and alcohol drinking patterns. The research uses rodent models to investigate how stress exposure alters sensitivity to alcohol's aversive effects and the neural circuits involved. The study employs classical and operant conditioning paradigms combined with...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Boston University $580,556 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of pituitary adenylate cyclase activating polypeptide (PACAP) in heavy alcohol drinking and associated anxiety-like behavior. The recipient will conduct mechanistic research using animal models of heavy alcohol drinking combined with pharmacological, molecular, and viral approaches to test whether the...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center-Shreveport $321,929 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. The recipient will conduct research into nitric oxide regulation and its role in alcohol tolerance development. The work employs operant conditioning and behavioral testing in mouse models, including medial prefrontal cortex-specific neurogranin knockout and overexpression variants, to investigate...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Trustees of The University of Pennsylvania $727,664 under the Alcohol Research Programs (CFDA 93.273) Project Grant on May 1, 2026. The award funds multi-omics spatial analysis of single mouse brain neurons and astrocytes in response to ethanol challenge to advance understanding of alcohol use disorder. The work examines how chronic ethanol exposure alters the open-chromatin landscape and cytoplasmic transcriptome of neurons,...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $167,500 in Project Grant funding to the University of Massachusetts Medical School on September 17, 2025, through the Alcohol Research Programs (CFDA 93.273) for a research study investigating sex differences in excessive alcohol use patterns across young adulthood and middle age. The research will utilize longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine how...
- The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Minnesota $400,585 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the spinal mechanisms of alcohol-induced tactile hypersensitivity. The research addresses the relationship between chronic alcohol consumption and heightened pain sensitivity in individuals with alcohol use disorder. The...
The National Institute on Alcohol Abuse and Alcoholism awarded the University of Massachusetts $416,315 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to identify neural circuit functional plasticity underlying hedonic tolerance to alcohol and other rewards in a rat model of chronic alcohol exposure. The research characterizes how chronic intermittent ethanol exposure affects behavioral measures of hedonic tolerance for both alcohol and non-alcohol rewards, measuring individual and sex-specific tolerance profiles and the impact of abstinence on tolerance. The work focuses on neural activity in the orbitofrontal cortex in the context of behavioral assays developed during the research, identifying neural circuit changes associated with the development and recession of hedonic tolerance and testing the hypothesis that disruption of neural systems underlying positive affect is a key component of hedonic tolerance development. Performance occurs in Hadley, Massachusetts, with a period of performance from August 1, 2026, through July 31, 2028. The award is classified as a Project Grant under the R21/R33 mechanism responsive to NIAAA PAR-21-250 (Mechanisms of Alcohol Tolerance).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.3k | 8/3/26 |