Project Grant R21AA031788
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Arkansas for Medical Sciences $561,966 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of oligodendrocyte-lineage cells in fetal alcohol spectrum disorder. The research defines mechanisms by which ethanol causes pathology in the developing central nervous system, with a focused goal of determining how oligodendrocyte-lineage cells and myelination contribute to...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $567,832 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research on reducing alcohol drinking through a nonmuscle myosin II small-molecule inhibitor targeting alcohol use disorder. The research focuses on disrupting alcohol-seeking and drinking behaviors in alcohol-dependent animal models using a first-in-class nonmuscle myosin II inhibitor...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of New Mexico Health Sciences Center $160,744 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate electrophysiological mechanisms of prenatal alcohol exposure (PAE) effects on cognitive control. The project combines translational touchscreen testing and in vivo electrophysiology to determine how PAE impairs executive function domains in mouse models. The research hypothesizes that...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Mississippi Medical Center $930,571 on September 23, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate behavioral responses to opioid-alcohol combinations and the role of mu opioid receptor neurogenetic variation in vulnerability to combined substance use. The research evaluates how a functional variant of the mu opioid receptor (C77G polymorphism) in genotyped rhesus monkeys influences...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center-Shreveport $321,929 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. The recipient will conduct research into nitric oxide regulation and its role in alcohol tolerance development. The work employs operant conditioning and behavioral testing in mouse models, including medial prefrontal cortex-specific neurogranin knockout and overexpression variants, to investigate...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
- The National Institute on Alcohol Abuse and Alcoholism awarded Children's Research Institute $648,180 on June 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms and potential pharmacotherapy of neurocognitive deficits in fetal alcohol spectrum disorders. The research examines the long-term neurobehavioral impact of prenatal alcohol exposure, with focus on apolipoprotein E (APOE) signaling in the motor cortex as a therapeutic target. The project builds on...
The National Institute on Alcohol Abuse and Alcoholism awarded the University of Mississippi Medical Center $409,500 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate morphological and molecular alterations at nodes of Ranvier in alcohol use disorder. The research examines whether alcohol abuse in humans with alcohol use disorders and in experimental rats produces alterations in node of Ranvier morphology and distribution of extracellular matrix molecules critical to assembly and maintenance of these myelin-bare regions of myelinated axons. The project tests the hypothesis that structural changes (reduced node length) and molecular changes in the node environment occur in both prefrontal and occipital cortical white matter in alcohol use disorders, and that overexpression of node-associated proteoglycans in the prefrontal cortex will increase while suppression will decrease alcohol drinking in experimental rats. Prior work by the research team found that levels of glial node proteoglycans, neurofascin 186, and node length are altered in prefrontal cortex of animal models and human subjects with depression; this project extends that investigation to understand whether similar disturbances contribute to defective brain connectivity in alcohol use disorders. The award period runs from July 16, 2026, through June 30, 2028. Work is performed in Mississippi.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($3k) | 7/30/26 | ||
| Not listed | $412.1k | 7/27/26 |