Project Grant R21AA031567

Award Date 9/17/24
Completion Date 8/31/26
Dollars Obligated $469K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Tallahassee, FL 32306, USA
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This federal Project Grant award for $469,330 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) aims to investigate the role of the skeletal muscle circadian clock in the development of alcohol-associated muscle disease (AAMD). The research, to be conducted by Florida State University from September 2024 to August 2026, will have two key objectives:

  1. Determine whether disruption to the skeletal muscle core molecular clock contributes to the decreases in contractile function caused by chronic alcohol use.

  2. Define the role of alcohol and alcohol-related factors in the disruption of the skeletal muscle clock, examining the influence of both peripheral circulating factors produced during alcohol metabolism and central (brain-specific) administration of alcohol on circadian function within the skeletal muscle.

This comprehensive investigation will be the first of its kind in studying the effects of alcohol on core clock function in skeletal muscle and lay the foundation for further research to understand the role of the core molecular clock in the development of AAMD.

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