The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This federal Project Grant award of $151,869, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research to investigate the relationship between chronic alcohol consumption, metabolic dysfunction, and the progression of Alzheimer's disease (AD). The key objectives of this 2-year project include: 1) assessing the impact of chronic ethanol exposure on metabolic function and tau pathology in an AD mouse...
This $442,898 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to define the contributions of macrophage migration inhibitory factor (MIF) and its receptor CD74 in alcohol-associated liver disease (ALD). The research plan includes three specific aims: 1) characterizing the role of CD74 expression in hepatocytes and myeloid cells during and after ethanol feeding in mice, 2) resolving the...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will provide $119,600 over a 3-year period from July 2024 to July 2027 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to conduct research on the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to identify how...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $123,045 to Louisiana State University Health Sciences Center New Orleans to investigate the role of the TRAF3IP2 protein in the pathogenesis of alcohol-related cardiomyopathy. The research aims to determine whether alcohol-induced cardiac fibroblast activation and inflammatory/fibrotic responses are dependent on TRAF3IP2, and whether global...
This Project Grant award of $1,158,934.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will fund research to understand the mechanisms of mitochondrial dynamics, quality control, and mitochondrial DNA-mediated inflammation in alcohol-associated liver disease (ALD). The key objectives are to investigate how chronically accumulated megamitochondria in the liver promote the release of mitochondrial DNA and activation of...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from September 1, 2024 to May 31, 2029. The project will investigate the role of KDM5 demethylases in regulating cell-cell communication in the development and resolution of alcohol-associated liver disease. Specifically, the research aims to determine how KDM5B and KDM5C...
This federal Project Grant award of $380,863 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research on the role of specific hepatic stellate cell subsets in the progression of alcohol-associated hepatitis (AH). The project aims to determine how the genes CYP1B1, PRRX1, and NR4A2 regulate the development and function of a novel FBLN2+ activated hepatic stellate cell (AHSC) subset in AH. Planned activities include...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to examine the role of non-parenchymal cells (NPCs) in driving the key features of Alcohol Associated Hepatitis (AAH) in a fully humanized mouse liver model. The $688,199 award to Yale University will fund research over a 5-year period from June 1, 2025 to February 28, 2030. The research aims to elucidate the NPC-derived...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $657,000 to Louisiana State University Health Sciences Center-Shreveport to investigate the role of lysophosphatidic acid (LPA) signaling in alcohol-induced blood-brain barrier disruption and neuroinflammation. The key objectives are to assess the effects of heavy alcohol consumption on mitochondrial function and redox balance, evaluate...