This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 to support research on the role of the GPR37L1 receptor in chronic migraine. The funding will enable a research team at Florida Atlantic University, with a sub-award to the University of Florida, to conduct a comprehensive investigation into the involvement of GPR37L1 signaling in the neuropathology of...
This Project Grant award of $455,371 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding the development and validation of a novel microchip-based platform for the discovery and characterization of migraine therapies. The key products and services to be delivered under this award include: Quantifying comprehensive neurovascular and behavioral responses to established migraine triggers and...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,831,197 to Emory University to conduct research on nociplastic pain mechanisms in temporomandibular disorders (TMD). The research project aims to separate nociceptive (stimulus-evoked) sensitivity from pain sensitivity using novel quantitative sensory testing methods, in order to better understand the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $129,454 to the University of Maryland, Baltimore to study the role of the SUR1-TRPM4 channel in chronic seizure susceptibility. The research aims to define how neuronal expression of this channel contributes to hyperexcitability and seizure activity, with the goal of...
This federal Project Grant award of $475,475 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate the role of circadian-driven complement activation and purinergic signaling as potential triggers of morning migraine. The research aims to define the...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will evaluate the safety and analgesic efficacy of a marine oil supplement containing specialized pro-resolving mediators for the treatment of chronic temporomandibular disorder (TMD) pain in adults. The $603,502 award will fund a 12-month, triple-masked, randomized, placebo-controlled clinical trial that...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand and potentially develop new treatments for neurological conditions such as pain and ischemic stroke. The $231,000 award, spanning from April 2025 to March 2027, will fund efforts at the University of Rochester to: 1) identify the binding...
This federal Project Grant award in the amount of $351,097 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), which is part of the National Institutes of Health (NIH). The grant was awarded under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279) to establish a rigorous and supportive interdisciplinary training program in clinical pain research at Mass General Brigham (MGB) in Boston. The program will support a diverse pool of 8 postdoctoral...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $620,278 to the University of Maryland, Baltimore to investigate the molecular basis for using sphingosine-1-phosphate receptor 1 (S1PR1) antagonists to treat the comorbid conditions of migraine and temporomandibular disorders (TMDs). The research aims to establish S1PR1 as a novel monotherapy target and determine the role of the NLRP3/IL-1β inflammatory pathway downstream of S1PR1 activation in the development of this chronic comorbidity. The project will use a multidisciplinary approach across independent laboratories to conduct behavioral and molecular pharmacology, electrophysiology, genetics, biochemistry, immunohistochemistry, and mass spectrometry studies. A sub-award of an unspecified amount was provided to Saint Louis University to contribute to this research effort.