Project Grant R15GM160971
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This Project Grant award of $150,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project at St. John's University, New York, focused on investigating the role of iron metabolism in regulating ferroptosis, a form of regulated cell death. The key objectives are to: 1) elucidate the molecular mechanisms by which the iron regulatory protein 2 (IRP2) influences ferroptosis...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
- The National Institute of General Medical Sciences (NIGMS), under the federal Biomedical Research and Research Training program (CFDA 93.859), awarded a $412,500 Project Grant to the University of South Florida. The grant supports a research program focused on understanding the molecular mechanisms of cell death and developing small molecule inhibitors to treat diseases associated with dysregulated cell death, including systemic inflammatory response syndrome (SIRS), infection, and heart...
- This $244,450 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the catalytic mechanisms, structural dynamics, and biomedical importance of two key classes of metalloenzymes: matrix metalloproteinases (MMPs) and iron(II)/2-oxoglutarate (2OG)-dependent oxygenases. The project, spanning July 2025 to June 2030, aims to provide missing knowledge on these...
This Project Grant award, valued at $559,543.00 and effective from September 5, 2025 to August 31, 2028, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to investigate the overlap between mitotic and ferroptotic pathways using novel hybrid small molecule inhibitors. Key products and services to be delivered include: This research is being conducted by the University of Toledo, a public research university with extensive experience in federal grant-funded projects across diverse scientific and technological domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $559.5k | 9/5/25 |