Project Grant R16GM153395
- This federal Project Grant award of $229,135 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to establish C18-ceramide as an essential factor for ferroptosis, a novel form of regulated cell death, and to elucidate the molecular mechanisms by which C18-ceramide interacts with the NCOA4 protein to regulate ferritinophagy and ferroptosis. The research, conducted by...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This $486,750 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel computational framework called "MOMO-SEQ" to study mammalian iron systems biology across multiple organs and cell types. The goal is to identify key biological mechanisms and features underlying various iron disorders, including iron deficiency, anemia, and iron...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
- This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $950,000 to The Research Foundation For The State University Of New York from February 2023 through January 2026. The award supports research into regulating iron homeostasis by controlling the fate of intracellular ferritin. A multidisciplinary team will use structural biology, spectroscopy, microscopy, proteomics, and other analytical tools to delineate the mechanisms determining...
- This Project Grant award, valued at $559,543.00 and effective from September 5, 2025 to August 31, 2028, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to investigate the overlap between mitotic and ferroptotic pathways using novel hybrid small molecule inhibitors. Key products and services to be delivered include: Characterization of a new class of small molecules capable of...
- The National Institute of General Medical Sciences (NIGMS), under the federal Biomedical Research and Research Training program (CFDA 93.859), awarded a $412,500 Project Grant to the University of South Florida. The grant supports a research program focused on understanding the molecular mechanisms of cell death and developing small molecule inhibitors to treat diseases associated with dysregulated cell death, including systemic inflammatory response syndrome (SIRS), infection, and heart...
- This Project Grant award, valued at $453,750.00 and awarded on August 8, 2025, supports research by The General Hospital Corporation (doing business as Massachusetts General Hospital) under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The research aims to explore how metabolic pathways control the transition between cell viability, pyroptosis (a lytic cell death program), and apoptosis (non-lytic cell death)....
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
This Project Grant award of $150,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project at St. John's University, New York, focused on investigating the role of iron metabolism in regulating ferroptosis, a form of regulated cell death. The key objectives are to: 1) elucidate the molecular mechanisms by which the iron regulatory protein 2 (IRP2) influences ferroptosis resistance, and 2) determine the impact of salinomycin-induced lysosomal changes on ferroptosis sensitivity. The project leverages an advanced cellular reporter system developed by the researchers to track changes in cellular iron levels and their relationship to ferroptosis. The findings from this 4-year project are expected to enhance the understanding of how iron metabolism genes regulate ferroptosis and their implications in physiological and pathological contexts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $150.0k | 9/1/25 |