Project Grant R15GM160954
- This Project Grant award of $317,089 from the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) supports the development of new tools to study the dynamics of molecular forces within living cells. The key products and services being delivered under this grant include: Creating a universal tension sensor to measure force loading rates with high resolution, including developing a library of...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a comprehensive research program to decipher the principles and mechanisms of cellular mechanosignaling. The Principal Investigator will leverage a multi-fluorescence biomembrane force probe platform, in combination with molecular/cellular engineering, super-resolution imaging, biophysical modeling, and molecular...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $576,411.00 in funding to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research into how enzymes regulate the communication between cells through physical "bridges" that can be severed. The project aims to uncover the mechanisms of how these enzymes, known as ADAM proteases, recognize and cleave these...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853), supports research to understand how G protein-coupled receptors (GPCRs) regulate cellular functions in cardiomyocytes and neurons. The $396,031 award to the Augusta University Research Institute, Inc. will map the subcellular distribution of heterotrimeric G proteins, investigate how G proteins move upon receptor activation, and determine if G proteins are concentrated at specific...
- This $398,598 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on mechanosensing mechanisms in intestinal epithelial cells. The principal investigator will use super-resolution functional imaging and in vivo interactomic approaches to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, investigate physiological...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
- The National Institute of General Medical Sciences (NIGMS) awarded a $249,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RFSUNY), doing business as Stony Brook University. The grant will fund a 3-year research project from September 1, 2025 to August 31, 2028 to study the "Dynamic Mechanisms of Transcriptional Coactivator Function in Notch Signaling." The research aims to...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $627,797 to Cornell University to conduct research on the molecular mechanisms connecting endocytic and junctional complexes with epithelial pathology in the C. elegans model organism. The goal of this 5-year research program is to delineate the inner workings of membrane-associated protein complexes required for...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
- This Project Grant award, totaling $422,173, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund research at the University of Massachusetts Boston to investigate cellular signaling networks that control organ growth and tissue patterning. The research will focus on three key signaling pathways: the RTK/ERK pathway, Hippo signaling regulation, and the functions of the kinase...
The Project Grant award of $555,000.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) for the project titled "The Endocytic Requirements for Mechanosensitive Notch Activation in vivo" with a performance period from September 1, 2025 to August 31, 2028. This award will fund fundamental scientific research to investigate the critical aspects of Epsin-mediated ligand endocytosis that allows the exertion of activating force across the Notch receptor-ligand bridge, which is an important process in Notch signaling and various biological functions. The research findings could lead to advancements in understanding and potentially treating human disorders and cancers related to dysregulated Notch signaling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.0k | 8/18/25 |