This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $123,956 Project Grant to New Mexico State University (NMSU) through the Biological Sciences program (CFDA 47.074) to support a 3-year research project. The project will probe the role of the small GTPase Rap1 protein in the mechanisms that drive morphogenesis - the changes in cell and tissue shape and arrangement during development. The goals are for the Principal Investigator to learn and apply...
This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
The National Science Foundation awarded a $945,996 project grant to the University of Florida's Division of Sponsored Research under the Biological Sciences program (CFDA 47.074). The grant supports research into intramembrane proteolysis in regulation of the rice receptor kinase XA21 from August 1, 2021 through July 31, 2025. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award will fund basic research into...
This $383,799 National Science Foundation project grant supports collaborative research to map protein-membrane interactions across molecular to cellular scales. Funded under the Biological Sciences program (CFDA 47.074), the research aims to better understand how integral membrane proteins and surrounding phospholipid membranes work together to enable cellular processes. The University of Arizona will conduct multiscale modeling from molecular dynamics simulations of single protein-membrane...
The National Institute of General Medical Sciences (NIGMS) has awarded a $424,231 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Augusta University Research Institute, Inc. in Augusta, Georgia. The objective of this 3-year project is to understand the fundamental mechanisms and functions of enzymes that catalyze the homologation (insertion of a methylene group) of amino acids in natural product biosynthesis. The research aims to determine the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,173 to the University of Massachusetts Boston to advance understanding of cellular signaling networks controlling organism development. The research aims to investigate three signaling systems that regulate key developmental processes of organ growth and tissue patterning. Specifically, the project will study...
This Project Grant award of $410,939 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Clemson University to elucidate the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, such as atomic force microscopy, to probe how membrane proteins interact with cell membranes, maintain proper orientation, and achieve their final folded state during...
This $820,000 Project Grant was awarded on July 15, 2023 by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant supports a collaborative research effort involving four research labs, two in the U.S. and two in Israel, to investigate RNA editing enzymes called ADARs (Adenosine Deaminases Acting on RNA). The goal is to advance the understanding of how ADAR enzymes can be used by different organisms to...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) will support research to investigate the roles of amino acid isomerization, a chemical modification that affects the structure and function of cell-cell signaling peptides. The $681,070 award to the Board of Regents of the University of Nebraska, which operates as the University of Nebraska, aims to provide critical insights into how living systems alter their cellular communication...