Project Grant R01NS144381

Award Date 7/1/25
Completion Date 6/30/28
Dollars Obligated $396K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Augusta, GA 30912, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $415,000.00 to Sanford Research to conduct research on the structure and function of G protein-coupled receptors (GPCRs). The research aims to gain a deeper understanding of GPCR signaling pathways and their physiological functions, which are critical for drug development as GPCRs are prime targets. The project...
This $382,436 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms regulating the synthesis, sorting, trafficking, and release of neuropeptides from dense core vesicles within neurons. The project aims to create new transgenic fly lines to directly visualize these intracellular processes in vivo using advanced microscopy techniques. Key...
This $416,625 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to develop innovative optical tools to control endogenous G protein-coupled receptors (GPCRs) in unmodified cells and in vivo, as well as GPCRs and endogenous G proteins at exclusive subcellular locations such as Golgi and nuclear membranes. The project also aims to investigate the molecular links...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $597,844 to The Regents of the University of California, San Francisco (UCSF) to map the functional G protein-coupled receptor (GPCR) signaling landscape in neurons and investigate how neurons distinguish between diverse neuromodulatory inputs. The...
This five-year $1.5 million Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund computer simulations and modeling of G-proteins, molecular machines, and other biomolecules at the University of Southern California. The grant supports research into understanding the control and mediation of life processes by G-proteins and related complexes, the role of ATP in specialized proteins and energy conversion processes, directional motions of...
This Project Grant award, with a total funding amount of $349,566.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award, granted on April 2, 2025, supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc., a for-profit company based in Tempe, Arizona. The SFNOA technology aims to address key challenges in the...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support the development of a multiparametric fluorescence microscopy framework to correlate metabolic changes with cellular manipulations and physical/biophysical properties. The award, granted to Georgetown University, will establish a seamless workflow to quantify and correlate fundamental cellular interactions, such as...
The National Institute of General Medical Sciences (NIGMS) awarded a $471,019 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Georgia TECH Research Corp, doing business as the Office of Sponsored Programs, for the project "Characterizing Extracellular Glycoproteins and Unraveling Their Functions" from February 1, 2025 to January 31, 2030. This project aims to develop innovative methods to comprehensively analyze glycoproteins on cell surfaces and in the...

This Project Grant award, valued at $396,031, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding supports research by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to map the subcellular distribution of heterotrimeric G proteins in cardiomyocytes and neurons. The goal is to improve understanding of how G protein-coupled receptors (GPCRs) signal from intracellular compartments in these excitable cells, which is essential for developing new treatments for cardiovascular and neurological diseases. The project uses advanced microscopy and spectroscopy techniques to track G protein trafficking and redistribution upon receptor activation. Broader objectives include developing bioluminescence resonance energy transfer (BRET) methods to study other signaling molecules and produce a comprehensive picture of GPCR signaling mechanisms.

Generated 7/15/25, 4:19 AM