The National Institute of General Medical Sciences (NIGMS) awarded a $340,920 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The goal of this 5-year project is to develop novel top-down and native mass spectrometry approaches to directly characterize and quantify intact ribosomal proteins and determine the specialized components that assemble into heterogeneous ribosome structures. This research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research into the molecular mechanisms of ribosome biogenesis by force-producing enzymes. The $392,500 award to Rutgers, The State University of New Jersey will fund a 5-year project focused on characterizing how ATP-driven mechanoenzymes sequentially convert ribosomal precursors into mature ribosomes. Key activities...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $678,000.00 to Rockefeller University to conduct research on the mechanisms of eukaryotic ribosome assembly. The project aims to develop a detailed understanding of the co-transcriptional assembly and maturation of ribosomal subunits in the nucleolus, a crucial but poorly understood early stage of eukaryotic ribosome biogenesis. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $316,968.00 to Emory University to study the regulation, inhibition, and quality control mechanisms of ribosomes. The 5-year project, running from June 1, 2025 to May 31, 2030, will use biochemistry and structural biology approaches to investigate three key themes: 1) translation fidelity events like miscoding and frameshift errors,...
The National Institute of General Medical Sciences (NIGMS) awarded a $452,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective June 1, 2025 through April 30, 2030, supports research to decipher the functions of nuclear speckles in regulating protein quality control processes, which are crucial for cellular health and implicated in conditions like aging and neurodegeneration. The research aims to...
The National Institute of General Medical Sciences (NIGMS) awarded a $243,840 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The project, titled "An Effective Statistical Inference Framework to Develop Innovative Compensations for Protein Mutations," aims to develop quantitative methods for predicting the impact of protein mutations and identifying compensatory mutations that can restore normal protein...
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
This $1,084,158 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the University of Michigan's research efforts to investigate RNA-protein interactions (RPIs) and develop enabling technologies. Specifically, the grant funds three major research directions: 1) Further development of the university's live-cell RPI assay technology, RNA Interaction with Protein-mediated Complementation Assay...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $658,165.00 to Triad National Security, LLC to conduct advanced research on the effects of ions on mRNA, ribosomes, and antibiotic-RNA interactions. The research aims to deepen the understanding of ribosome mechanism and mRNA regulation at the atomistic level, with a focus on the bacterial ribosome. Key areas of...