The National Institute of General Medical Sciences (NIGMS) awarded a $366,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Central Michigan University. The grant, which runs from January 1, 2025 to December 31, 2029, aims to develop bioluminescent kinase sensors to monitor and manipulate cell signaling processes related to cell growth, division, and the cell cycle. The proposed research seeks to create novel tools for studying cell biology and...
This $249,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research on cellular stress response mechanisms in the annual killifish Austrofundulus limnaeus. The research aims to elucidate how these naturally stress-tolerant fish cells can decouple translation inhibition from stress granule formation, and investigate the role of mitochondrial-derived small non-coding RNAs in...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
The National Institute of General Medical Sciences (NIGMS) awarded a $715,109 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois to uncover novel heme chemistry in microbial systems. The research aims to establish how divergent bacterial diheme proteins stabilize high-valent bis-FeIV states and utilize these intermediates for site-specific substrate oxidation. Key objectives include addressing outstanding questions related to the...
This $222,852 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to computationally assess the impact of aging-related oxidative stress on the human proteome using a novel deep learning methodology. The project will construct a deep learning-based atomic protein structure embedding method to predict the likelihood of oxidation-related modifications occurring across the entire human proteome. The...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Oklahoma State University for $450,252 on August 12, 2024. The grant, titled "Brainstem Glial Senescence and Dysfunction in Obesity-Induced Hypertension," will fund research to investigate the role of glial cell dysfunction, specifically microglial senescence and impaired astrocytic glutamate reuptake, in obesity-induced sympathetic nervous...
The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This Project Grant award, valued at $1,380,568.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports an interdisciplinary research initiative led by the University of Chicago. The project aims to develop a multiscale, predictive understanding of how cells adapt to changes in their environment, with potential applications in innovative therapeutic interventions for diseases. The research is...
The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...
This Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the understanding of tissue-resident macrophage biology in vivo. The awardee, The Medical College of Wisconsin, Inc., will utilize a novel small vertebrate model, Danionella cerebrum, to systematically analyze the ontogeny, kinetics, and function of tissue-resident macrophages during homeostasis,...