The National Institute of General Medical Sciences (NIGMS) awarded Central Michigan University a $443,315 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) with a start date of September 1, 2023 and an ultimate completion date of August 31, 2026. The goal of this research project is to characterize the impact of social status on oxidative stress patterns and regulation across the brain. The research will use the cichlid fish Astatotilapia burtoni as a...
This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This $210,090 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant supports the University of Oklahoma Health Sciences Center's (OUHSC) efforts to enhance the success, retention, and well-being of biomedical doctoral students through proven and innovative training approaches. Key objectives include modernizing curriculum, training mentors, creating a peer...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $644,687 to the University of Missouri System to conduct research on a neural circuit in the brain that contributes to hypertension associated with obstructive sleep apnea. The research aims to determine how this "orexin-CRH-NTS" circuit facilitates the peripheral chemoreflex and leads to sympathoexcitation and hypertension,...
This $1,549,956 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research at The Ohio State University to understand the role of the O-GlcNAc Transferase (OGT) enzyme in host defense mechanisms against viral and bacterial infections. The research aims to elucidate how OGT senses pathogen infection and integrates innate immune signaling and cellular lipid metabolism through both...
The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...
The Department of Health and Human Services' National Institute of General Medical Sciences awarded Oregon Health & Science University a $2,680,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2022 through August 31, 2025. The grant will support research to elucidate signaling pathways of the P2X7 purinergic receptor and develop novel small molecule and aptamer ligand therapies. Specifically, the recipient will utilize...
The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
The National Institute of General Medical Sciences (NIGMS) awarded a $445,000 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the Beckman Research Institute of the City of Hope. The grant, awarded on February 1, 2025, will fund research over a 5-year period until January 31, 2030. The key objectives of the project are to: Dissect the structural basis of allosteric modulation by the third intracellular loop (ICL3) of G protein-coupled...