Project Grant R15EB036962
Award Date
5/1/25
Completion Date
4/30/28
Dollars Obligated
$882K
Federal Agency
National Institute of Biomedical Imaging and Bioenginering
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Texas, USA
Similar Awards
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), provides $622,000.00 to The Washington University in St. Louis to research and develop extracellular vesicle (EV) technologies for the targeted delivery of therapeutic molecules. The key objectives of this 3-year project are to utilize vascular endothelial...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $298,999 to Numentus Technologies Inc. to develop a high-throughput, high-content nanoscale extracellular vesicle (EV) analysis platform. The project aims to create a novel imaging technology capable of rapidly analyzing up to 10 million dispersed EV particles from clinical samples like blood, saliva, or stool....
This federal Project Grant award, valued at $1,404,189.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The award, with a start date of June 1, 2024 and an ultimate completion date of February 29, 2028, is being used by William Marsh Rice University to develop new capabilities for engineering human cells using robust and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $734,880 to Texas A&M AgriLife Research to support research on the mechanisms of extracellular vesicle (EV) release, function, and clearance. The award period runs from September 5, 2024 to August 31, 2029. The research aims to advance the basic cell biological understanding of EV biogenesis, targeting, cargo transfer, and...
This federal Project Grant award, valued at $356,497 and awarded on August 15, 2024, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant supports the development of an ultrasensitive flow cytometry system for the multiparametric analysis of therapeutic anti-aging extracellular vesicles (EVs). Extracellular vesicles are small, lipid-bound vesicles secreted by cells that show promise as...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to establish a targeted therapeutic microRNA (miRNA) delivery system using engineered cell-derived extracellular vesicles (EVs) to target epidermal growth factor receptor (EGFR) cancers. The $351,517 award, made on August 26, 2024, will fund research to engineer EV surfaces with antibody mimetics to target EGFR-positive cancer cells and deliver tumor suppressor miRNAs. The...
The National Cancer Institute awarded a $662,946 Project Grant (R01CA284182) to The Trustees of the University of Pennsylvania to develop designer extracellular vesicles (EVs) derived from engineered natural killer (NK) cells as an effective cell-free immunotherapy for treating melanoma, the deadliest form of skin cancer. The key products and services to be delivered under this Cancer Treatment Research (CFDA 93.395) program include: Optimizing the cytotoxicity and immune-stimulatory functions...
This $712,479 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) supports the development of a modular, logic-gated split chimeric antigen receptor T (CAR T) cell therapy platform for treating solid tumors. The key objectives are to: 1) Establish a split CAR T cell format that can respond to both tumor cell surface proteins...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
This Project Grant award, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports research and development of machine learning-enabled classification of extracellular vesicles using nanoplasmonic microfluidics. The total award amount is $576,716.86 over the project period from September 12, 2024 to August 31, 2027. The research aims to develop...