Project Grant R15DK144843
- This Project Grant award of $546,831.44 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the melanocortin-3 receptor (MC3R) in neural circuits regulating feeding, stress, and anxiety behaviors. The research aims to elucidate how MC3R neurons and the bed nucleus of the stria terminalis (BST) function as an integration hub for...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,074,199 to the Albert Einstein College of Medicine to conduct research on the top-down regulation of feeding-related behavior. The research aims to define the connectivity between hypothalamus melanocortin peptide expressing neurons and melanocortin 4 receptor (MC4R)-expressing neurons...
- This Project Grant award of $666,229 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of the neuropeptide neurotensin (NTS) in the lateral nucleus accumbens (NACLat) to ventral tegmental area (VTA) pathway and its impact on hedonic feeding behavior. The project aims to study how NTS signaling in this neural pathway modulates reward-related feeding in mice, both on...
- This Project Grant award, totaling $502,233, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Regents of the University of Michigan to investigate neuron populations in the nucleus of the solitary tract (NTS) that mediate the aversive and non-aversive suppression of food intake. The research aims to further...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $453,000 to East Carolina University to determine the role of FGFR1 signaling in agouti-related protein (AGRP) neurons for regulating metabolism. The research aims to establish a previously unknown signaling pathway of FGFR1-PI3K-FOXO1 in AGRP neurons that contributes to...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $136,449 to The Regents of the University of California, doing business as the University of California, Berkeley, to evaluate the role of human obesity genes in specific neuronal populations using a CRISPR-based approach. The research aims to determine how genetic variation...
- This Project Grant award of $249,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to New York University aims to improve understanding of how hunger and satiety neurons regulate the activity of downstream neurons in the hypothalamus. Specifically, the research will use novel molecular and optical tools to measure and manipulate cyclic AMP (cAMP) signaling in paraventricular hypothalamic neurons that express melanocortin-4 receptors (PVHMC4R), which...
- This Project Grant award, totaling $123,908, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Baylor College of Medicine to investigate the role of the ANO4 calcium-activated chloride channel in the area postrema (AP) region of the brain, and its potential involvement in the orexigenic (appetite-stimulating) effects of the...
- This federal Project Grant award in the amount of $427,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to President & Trustees of Williams College. The award is funding a research project to study the role of the parasubthalamic nucleus (PSTN) in regulating feeding behavior and appetite suppression. The key objectives are to determine the afferent...
- The $441,000 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research by the CAL Poly Pomona Foundation Inc. to identify a dopamine circuit in the brain that mediates day eating and diet-induced obesity in mice. The 3-year project seeks to genetically and anatomically define a subpopulation of dopaminergic neurons in the ventral tegmental...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $559,918 to Florida Atlantic University (FAU) to research how naturally occurring genetic variation shapes feeding behavior and metabolism. The project, titled "Decoding the Role of Naturally Occurring Variation in Genetic and Neural Regulation of Feeding and Energy Homeostasis," leverages the blind Mexican cavefish (Astyanax mexicanus) as a model organism to investigate the functions of the melanocortin 3 (MC3R) and melanocortin 4 (MC4R) receptors in regulating feeding and metabolism. The award period is from September 8, 2025 to August 31, 2028. The research aims to advance the understanding of how genetic architecture influences metabolic disorders, with potential implications for improving prevention, diagnosis, and treatment of conditions such as metabolic syndrome and diabetes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $559.9k | 9/9/25 |