This $445,500 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research at the University of Alabama at Birmingham (UAB) to investigate the effects of chronic cocaine exposure on the nervous system of the nematode Caenorhabditis elegans. The research team will generate comprehensive molecular, behavioral, and neuronal activity atlases to identify genetic regulators underlying drug-induced plasticity...
This $492,000 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund a research project at the University of Chicago to elucidate the genetic and epigenetic factors underlying cocaine addiction. The key objectives of the project are to: 1) conduct high-resolution chromatin accessibility and DNA methylation profiling to delineate cell-type and circuit-specific epigenetic...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,127,388 to the University of Florida to investigate the role of the neuronal protein Rac1 in cocaine addiction and seeking behavior. The research aims to determine how Rac1 activity within neuronal ensembles mediates the behavioral, structural, and functional changes that drive cocaine-seeking, with the goal of identifying new...
The National Institute on Drug Abuse (NIDA) awarded a $272,395 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Regents of the University of California, San Francisco (UCSF) to research the role of the epigenetic regulators G9A and GLP in the development of addictive behaviors. The key objectives are to: 1) Identify specific molecular surfaces that enable manipulation of the different G9A/GLP dimers and their chromatin binding activities, and 2) Examine how...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $284,040 to the Lieber Institute for Brain Development to conduct research on the molecular mechanisms underlying opioid addiction. The project aims to use integrated single-cell and spatial transcriptomic approaches to map gene expression changes in specific cell populations and projection neurons within the habenula, a key brain region...
This $175,888 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to develop novel methods for studying the genetic and neurological mechanisms underlying nicotine and cannabis addiction. The key products and services to be delivered under this 4-year grant include: Developing a new Transcriptome-Wide Association Study (TWAS) method to identify genes associated with changes in brain functional connectivity...
The National Institute on Drug Abuse (NIDA) awarded a $694,219 Cooperative Agreement (CFDA 93.279 - Drug Use and Addiction Research Programs) to the University of California, Los Angeles (UCLA) to identify genes involved in behaviors related to substance use disorder. The project aims to use a novel mechanism-to-gene strategy, integrating genetic and circuit variation, to map the genetic underpinnings of anxiety-related behaviors linked to substance use disorders. Key objectives include...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to identify genes and molecular mechanisms that affect psychostimulant-induced sleep irregularities and the impact of sleep deprivation on drug preference in the vinegar fly (Drosophila melanogaster). The $458,452 award, spanning from June 1, 2025 to February 28, 2030, will fund investigations into: 1) the mechanisms of stimulant-induced sleep changes,...
The National Institute on Drug Abuse (NIDA) awarded a $215,613 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Alabama at Birmingham (UAB) to study the role of the reelin protein in the cellular and behavioral responses to drugs of abuse. The research aims to investigate how reelin signaling regulates membrane excitability and dopamine signaling to facilitate the development of cocaine addiction. Key activities include using RNA single-molecule...
This $267,310 federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research at the University of Miami to investigate the role of parabrachial CGRP neurons in opioid reinforcement and withdrawal. The project aims to assess the functional role of these neurons in opioid-related behaviors and determine the associated gene expression and epigenetic changes. Specifically, the researchers will inhibit the...