Project Grant R15CA313429
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Virginia $161,500 under the Cancer Biology Research program (CFDA 93.396) to develop innovative methodologies for classifying circulating tumor cells (CTCs) with hybrid epithelial and mesenchymal phenotypes in pancreatic ductal adenocarcinoma (PDAC). The project, active from June 1, 2026, through May 31, 2028, delivers a perfusable co-culture system and microfluidic analytical platform designed to...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Texas Southwestern Medical Center a $683,885 Project Grant under the Cancer Treatment Research program (CFDA 93.395) for the period of May 1, 2026 through April 30, 2031. This award supports the development of the first clinical prototype for Proton Minibeam Radiation Therapy (PMBRT), an advanced spatially fractionated radiation therapy modality designed to improve therapeutic outcomes in cancer...
- Grant Award Summary The National Cancer Institute (NCI) awarded $635,749 under the Cancer Biology Research program (CFDA 93.396) to The University of Texas Health Science Center at San Antonio for the project "Charting Cellular Attraction-Based Interactome with Multivalent Adhesive Probe AFM (MAPA)" (Award Date: September 1, 2025; Completion Date: August 31, 2028). This three-year Project Grant funds the development and validation of advanced atomic force microscopy (AFM) technology...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a five-year Project Grant totaling $639,514 to The University of Texas Southwestern Medical Center (UT Southwestern) under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026, through May 31, 2031. The award supports fundamental cancer biology research focused on characterizing the catalytic mechanisms of NVL (a nucleolar AAA+ adenosine triphosphatase) inhibition by benzothiazepinone...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $411,583 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective August 1, 2025, through July 31, 2027. This award supports the development and validation of a computational model that characterizes the relationship between perivascular spaces and interstitial fluid flow in glioma invasion. The project...
- Federal Project Grant Award Summary The University of North Texas received a $148,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective September 5, 2025, through August 31, 2027. The research evaluates the role of extracellular vesicles (EVs) in tumor microenvironment modulation, with a specific focus on identifying mechanisms of T cell suppression in non-small cell lung cancer (NSCLC) and other immune-cold tumors. The...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center (UT Southwestern) under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. This five-year award funds fundamental research investigating the KEAP1-NRF2 redox sensing pathway's role in regulating CD8 T cell adaptation and stemness in the context of cancer and chronic infection. The research...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $388,546 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) effective June 1, 2026 through May 31, 2031. The research initiative, titled "Targeting the Golgi Secretory Pathway in Chromosome 3Q-Amplified Human Cancer," addresses the critical gap in targeted therapies for non-small cell lung cancer (NSCLC) lacking actionable mutations in KRAS...
Texas Tech University received a $607,488 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period June 1, 2026 through May 31, 2029. This award supports the development and validation of the HU Microchip platform, an innovative microfluidic technology designed to isolate and profile circulating tumor cells (CTCs) with enhanced sensitivity to epithelial-mesenchymal transition (EMT) states. The research addresses a critical gap in cancer diagnostics by enabling the separation and characterization of CTC subpopulations that exhibit varying degrees of epithelial and mesenchymal properties, which are associated with metastatic potential. The project delivers a microfluidic-based diagnostic platform integrated with deep learning-based profiling capabilities that utilizes micro and nanometer-scale cellular features extracted from microscope imaging to achieve high-accuracy identification of CTC subtypes. By combining advanced isolation technology with artificial intelligence-driven analysis, the deliverable represents a translational research tool intended to improve cancer patient stratification and monitoring capabilities. The work is conducted at Texas Tech University's facilities in Texas and is expected to generate fundamental insights into CTC plasticity during cancer progression that can inform future clinical applications in early detection and disease management.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $607.5k | 6/3/26 |