Project Grant R61CA291213
- This federal Project Grant award in the amount of $449,625.00 was issued on September 15, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports the development of statistical methods to quantify heterogeneous cell-cell interaction patterns in spatial transcriptomics data across various human diseases, including pancreatic cancer, gastric cancer, and Alzheimer's disease. The key products...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- The federal Project Grant award of $186,250.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Virginia to develop and characterize membrane-sensitive fluorescent probes for measuring local membrane environments of membrane proteins in living cells. The key objectives are to: 1) calibrate various fluorescent sensors to specific membrane structural parameters and determine their spatial sensing range, and 2) demonstrate proof-of-concept...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $349,681 to the University of Maryland, College Park to develop force nanoprobes that can map intracellular forces in living cells. The goal is to advance the understanding of how cells process mechanical cues, which is critical for addressing diseases associated with dysregulated mechanical communication. The force...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,135 to develop a new magnetics-based method for rapidly mapping the mechanical properties of tissues. The goal is to address technical limitations of current scanning probe methods used to study the tumor microenvironment and its impact on T cell function in solid tumors. The award will fund the development and...
- This federal Project Grant award, valued at $401,829.00 and awarded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports innovative research by Weill Medical College of Cornell University to develop transformative methods for high-throughput single-cell mapping of DNA-binding proteins. The project, titled "Precision Single-Cell Mapping of Chromatin-Associated Protein Activity by Molecular Footprinting to Chart Disruptions to Gene Regulation...
- This $600,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program aims to develop an innovative Optomagnetic Twisting Cytometry (OMTC) system to quantify the dynamic viscoelastic properties of 3D tissue samples. The project will construct an optical scanning system to enable simultaneous measurements of hundreds of thousands of microparticles within a large field-of-view, advancing the understanding of the mechanical properties of live...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
This Project Grant, titled "CHARTING CELLULAR ATTRACTION-BASED INTERACTOME WITH MULTIVALENT ADHESIVE PROBE AFM (MAPA)", is funded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) in the amount of $635,749. The grant was awarded to The University of Texas Health Science Center at San Antonio and aims to develop and validate a new technology using atomic force microscopy (AFM) to analyze the adhesive properties and surface chemistry of live cells. The proposed research seeks to map the dispersive adhesion of cells based on van der Waals interactions, which is particularly relevant for studying the behavior of invasive cells like circulating tumor cells. This advanced biophysical tool is intended to provide unprecedented insight into the fundamental mechanisms governing cell-cell interactions, which are critical for processes like organism development, tissue integrity, immune response, and cancer metastasis. The project period runs from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $635.7k | 8/15/25 |