Project Grant R03TR006293
- Federal Grant Award Summary Icahn School of Medicine at Mount Sinai received a $462,454 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 8, 2025 through June 30, 2027. The award supports research investigating DNA methylation (5-methylcytosine) dynamics in Down syndrome (trisomy 21) hematopoiesis and leukemia development. The primary deliverable involves mapping epigenetic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a $1,175,924 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective April 1, 2026, with completion targeted for January 31, 2033. Under this award, the institution will conduct fundamental research investigating hemogenic mesoderm heterogeneity, regulation, and function in the mammalian hematopoietic system. The research program aims to elucidate...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Icahn School of Medicine at Mount Sinai $871,028 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a project addressing ineffective erythropoiesis in myelodysplastic syndrome (MDS). The award, effective March 1, 2026, through December 31, 2030, supports basic biomedical research to characterize the mechanisms by which iron...
- Federal Project Grant Award Summary Boston Children's Hospital received an $801,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with a completion date of July 31, 2030. This award supports research investigating the role of stress granules in red blood cell development and erythropoiesis, specifically examining...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $1.476 million Project Grant award dated September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) from the National Institutes of Health (NIH) Office of the Director. The award supports a three-year research initiative (completion date: August 31, 2028) titled "Engineering Enhanced Erythropoiesis for Red Blood Cell Disorders," which addresses critical limitations in...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $168,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS), CFDA 93.350, awarded May 1, 2026, with completion scheduled for April 30, 2028. The grant funds research to develop and validate a three-dimensional lung organoid model that recapitulates early fetal lung development. The primary deliverable is characterization of cystic fibrosis transmembrane conductance regulator...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $327,240 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 9, 2025, with completion targeted for March 31, 2028. The grant funds research to elucidate the interplay between DDX41 (Dead-Box Helicase 41) and CUX1 (Cut-Like Homeobox 1) mutations in hematopoiesis using zebrafish (Danio rerio) and human induced...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a $1,458,543 Project Grant on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a versatile paired prime editing toolkit for cystic fibrosis transmembrane conductance regulator (CFTR) gene correction. The research will advance genome editing techniques to address the therapeutic challenge posed by over 1,700...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded Boston Children's Hospital $117,525 on July 7, 2025, to investigate cellular adaptation mechanisms in response to one-carbon (1C) metabolism perturbation, with project completion targeted for June 30, 2028. The research will characterize how cells respond to folate depletion by examining the role of ufmylation, a post-translational...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded $422,916 in project grant funding under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany, effective August 1, 2025, through July 31, 2027. This project grant supports investigator-initiated biomedical research designed to advance understanding of human...
The National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded $168,000 to Icahn School of Medicine at Mount Sinai, effective July 1, 2026 through June 30, 2027, to investigate the role of the INTS12 protein in transcription elongation control during human red blood cell development and in Congenital Dyserythropoietic Anemia Type IV (CDA IV), a rare hemolytic anemia affecting children. The project will utilize the newly established BEL-A erythroid progenitor cell line to conduct comparative studies of normal and CDA IV mutant cells, examining INTS12 chromatin binding patterns, transcription factor interactions, and the effects of INTS12 depletion and overexpression on red cell development. The research deliverables will advance understanding of how reduced INTS12 levels contribute to ineffective erythropoiesis and transcriptional dysregulation in CDA IV patients. Findings from this translational science initiative will generate data on RNA polymerase II elongation control mechanisms and may inform therapeutic approaches for this transfusion-dependent pediatric disorder, aligning with NCATS's mission to accelerate the translation of research observations into practical health solutions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.0k | 6/16/26 |