The federal Project Grant award, with ID R35GM156454, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award, totaling $440,000.00 and granted on February 3, 2025, supports a research program focused on in-depth exploration of the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteome homeostasis or proteostasis. The key objectives of this project are to...
This R03 project grant, awarded by the National Center for Advancing Translational Sciences (NCATS) under CFDA Program 93.350, aims to comprehensively identify metabolic enzymes that control the generation of TCF1+ progenitor CD8+ T cells, which are critical for durable anti-tumor immune responses. The $169,500 award, spanning from September 1, 2024 to August 31, 2026, will fund two key research objectives: Identifying metabolic enzymes whose loss alters T cell differentiation and the TCF1+...
This $528,129 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human diseases. The overarching goal is to develop a detailed understanding of how ubiquitin-proteasome pathway (UPP) components recognize substrates and execute their function, which is crucial for developing new...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $918,400.00 to The University of Texas Southwestern Medical Center to study the impact of a specific ITPR3 gene mutation on immunity, neurology, and eccrine functions. The research aims to characterize the effects of this mutation on T and B cell signaling, as well as the impact on Schwann cells and eccrine...
The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $288,240 Project Grant (CFDA 93.350) to the La Jolla Institute for Immunology. The grant, titled "Linking Specific Phosphorylation Events to Distinct Transcriptional States", aims to develop an innovative data-driven technology solution integrating global, temporally-resolved transcriptomic and phosphoproteomic data with statistical modeling. This will systematically identify...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), funded under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the post-transcriptional control of gene expression by the mTORC1 signaling pathway. The $837,500 award to Yale University, running from August 2024 to June 2029, aims to address fundamental questions about the mechanisms regulating cap-dependent and cap-independent translation of mRNAs, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the impact of a patient mutation on the non-canonical, autophagy-independent activities of the ATG3 protein. The $242,310 award, spanning July 2024 to July 2026, will enable the development of tools to understand the cell biological consequences of these non-canonical ATG3 activities and evaluate the effect of...
This $388,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS), CFDA 93.859 Biomedical Research and Research Training program, supports research to elucidate how cis-regulatory elements (CREs) in T cells modulate epigenetic programming during thymic development and contribute to chronic diseases. The goal is to establish a new model to test how human CREs harboring disease-associated variants regulate gene expression and long-term epigenetic changes in T cells,...
This $261,017 Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) supports the development of an innovative mouse model system for targeted trimming of disease susceptibility loci. The goal is to streamline the identification of causative genes within large susceptibility loci, which can contain multiple genes and non-coding regulatory elements, in order to advance disease mechanism research and new therapeutic development....
This Project Grant award for $380,540 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to decipher novel principles of rapid proteostatic control and develop innovative spatiotemporal lysosomal tools. The study aims to define novel protein substrates and peptide motifs required for lysosomal delivery, determine the functional impact of rapid methyl-driven lysosomal proteolysis as a cellular...