This federal Project Grant award of $149,294 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the role of the Zic2 transcription factor in regulating Hedgehog signaling and chromatin dynamics in the developing zebrafish forebrain. The University of Wisconsin-Madison is conducting this 1-year research project to identify Zic2...
This $521,209.45 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, supports research to delineate the role of the transcriptional repressor ZEB2 in human neural crest cell formation, craniofacial differentiation, and Mowat-Wilson syndrome. The 3-year award to The Research Foundation for the State University of New York (RF SUNY) will fund investigations into the...
The University of Texas Southwestern Medical Center was awarded a $502,104 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) by the National Institute of Child Health and Human Development (NICHD). The grant, titled "Molecular Mechanisms of Wntless in Zaki Syndrome and Wnt Secretion", will fund research to elucidate how mutations in the Wntless (WLS) gene affect Wnt protein secretion and contribute to the severe developmental...
This federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $216,000.00 to the University of California, San Diego (UCSD) to elucidate the function of CTCF, a key protein involved in chromatin organization, in neural differentiation and neurodevelopment. The research will employ both 2D and 3D human cell models to examine the role...
This Project Grant award of $1,819,296.00, issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to unravel the genomic causes for unsolved leukodystrophy patients. The award will utilize long-read genome sequencing (HiFi-GS) to identify complex genetic variants, such as repeat expansions and structural variants, that are often missed by standard short-read genome...
This Project Grant award of $743,926 from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will develop a resource of rigorously validated, translatable zebrafish models of previously undiagnosed human genetic diseases. The project will analyze genetic variants obtained from patients with rare, undiagnosed diseases through collaboration with clinical research consortia, and then generate humanized zebrafish models using CRISPR/Cas9 technology....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, aims to advance the understanding of how homeodomain (HD) transcription factors (TFs) regulate gene expression and impact human health. The $510,390 award to the Children's Hospital Medical Center in Cincinnati, Ohio will fund a 5-year research program to investigate the mechanisms underlying HD TF DNA binding specificity, the functional impact...
This $3.386 million project grant from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will fund research at Beth Israel Deaconess Medical Center to develop a potential treatment for Down syndrome. The grantee will assess the efficiency of using a modified CRISPR approach and single nucleotide polymorphism-based guide RNA targeting to silence one of three copies of human chromosome 21 in the Tc1 mouse model of Down syndrome. If successful, this research could...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $451,000.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to develop CRISPR interference (CRISPRi) technology and induced pluripotent stem cells (iPSCs) to identify genes on human chromosome 21 that contribute to Down syndrome pathologies. The goal is to build tools for high-throughput screens to pinpoint genes involved in the reduced...
The Broad Institute, Inc. was awarded a $158,000 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program. The award will support the establishment of foundational tools and datasets to investigate the function of the NSD1 gene in neural development. Specifically, the project will generate novel isogenic human induced pluripotent stem cell (iPSC) models of NSD1 haploinsufficiency and assess the dysregulation of histone H3 lysine 36...