This $451,000 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop tools to identify genes on human chromosome 21 that contribute to Down syndrome pathologies. The award recipient, The University of Texas Southwestern Medical Center, will use CRISPR interference technology and induced pluripotent stem cells derived from individuals with Down syndrome to conduct high-throughput...
This $3.44 million project grant from the Department of Health and Human Services National Institutes of Health Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), will fund research at the University of Massachusetts Medical School to suppress aneuploidy-associated phenotypes in Down syndrome. Specifically, the researchers will identify the mechanisms by which an extra copy of chromosome 21 affects nuclear structure and function in cells, investigate how...
The Trustees of the University of Pennsylvania received a $3.7 million Project Grant award from the Department of Health and Human Services National Institutes of Health Office of the Director to address co-occurring conditions in individuals with Down syndrome. Funded under the Trans-NIH Research Support program (CFDA 93.310), the three-year project will test whether reducing proteostatic stress with the FDA-approved small molecule 4-phenylbutyrate can ameliorate sleep deficits, metabolic...
This Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the cellular and synaptic mechanisms underlying cognitive disabilities in Down syndrome. The award to the University of Colorado-Denver will utilize a novel combination of two-photon microscopy, electrophysiology, chemogenetics, and pharmacological...
This federal Project Grant award, worth $2,010,230, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award will fund research at the University of California, San Diego (UCSD) to comprehensively investigate the intricate nuclear-metabolic interplay in Down syndrome (DS). The multifaceted study aims to characterize and modulate the nuclear-metabolic axis at three...
The National Institutes of Health (NIH) Office of the Director awarded a Project Grant of $1,896,457.00 under the Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "BRAIN DEVELOPMENT IN DOWN SYNDROME DURING FETAL AND EARLY POSTNATAL AGES". The grant, awarded on Sep 18, 2024, aims to confirm earlier findings on brain abnormalities in Down syndrome (DS) using advanced...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000 to the Regents of the University of Michigan to conduct research on the molecular regulators of the GABAergic system in human neurons derived from control and trisomy 21 (Down syndrome) human embryonic stem cells. The primary goal is to discover the underlying mechanisms that cause...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
This $5.2 million project grant from the Department of Health and Human Services National Institutes of Health Office of the Director, under the Trans-NIH Research Support program, will fund research at the University of Colorado Denver to study neurovascular dysfunction in individuals with Down syndrome revealed by traumatic brain injury. Over three years, the collaborative multi-principal investigator team will establish how trisomy 21-related cellular defects and candidate genes exacerbate...
This Project Grant award, totaling $780,000.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to elucidate the epigenetic mechanisms responsible for allelic inactivation of protein-coding genes within the Down Syndrome Critical Region and the Alzheimer's Disease-associated APP gene on Chromosome 21. The research will utilize human and mouse cell-based assays to investigate the molecular and cellular mechanisms...