This federal Project Grant award for $163,344.00 was made by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research by the University of Colorado-Denver to investigate the role of thyroid hormone regulation, specifically type 3 deiodinase (DIO3), in driving sex differences in cardiovascular health outcomes. The study aims to determine how DIO3 expression in the heart differs between males and females, and how it may interact with estrogen levels to influence cardiac function and responses to myocardial infarction. This research is intended to address critical gaps in understanding the molecular mechanisms behind the higher risk of heart failure and mortality in women compared to men following cardiovascular events. The award period runs from September 1, 2024 to August 31, 2027.
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