This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $161,500 from August 1, 2024 to July 31, 2026 to the Rector & Visitors of the University of Virginia (UVA) to establish basic science-clinical collaborations and understand the molecular mechanisms underlying heterotaxy, a severe form of congenital heart disease (CHD) affecting 3-4% of CHD...
This Project Grant award of $744,305.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant funds a research project to examine the role of the transcription factor PHOX2B in maintaining the molecular, cellular, and network properties of retrotrapezoid nucleus (RTN) neurons, which are critical for regulating breathing and arousal in response to CO2 levels. The key objectives are to: 1)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $398,598 to the University of Virginia to conduct research on the signaling mechanisms and physiological consequences of mechanochemical sensing in epithelial cell microvilli. The research aims to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, understand the...
The University of Virginia will receive $238,794 from the Defense Health Agency under a Project Grant award to investigate the mechanisms of seizure-induced death in TSC model mice. The research, to be conducted from June 2023 through May 2025 in Charlottesville, Virginia, aims to further the Military Medical Research and Development program's goal of transforming military and public health through innovative biomedical research solutions. Specifically, the grant will fund the university's...
The University of Virginia (UVA) has been awarded a $444,125 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to investigate the impact of reduced phagocytosis (cell debris clearance) on Alzheimer's disease (AD) pathology. The project aims to test the hypothesis that decreased efferocytosis (clearance of apoptotic cells) can alleviate amyloid-beta induced pathology by enhancing debris processing and degradation in microglia. Specific...
The University of Virginia (UVA) received a $888,251 Project Grant award from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) to conduct research comparing the effectiveness of a hybrid versus lecture-based training approach for improving first responder competence in autism response. The project, titled "AUTISM RESPONSE PROTOCOL: COMPARING THE EFFECTIVENESS OF A HYBRID VS LECTURE-BASED TRAINING ON AUTISM COMPETENCE IN FIRST RESPONDERS", will...
This $1,592,860 federal Project Grant award, funded by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420), supports ultrasensitive proteomics research at the University of Virginia. The research aims to develop advanced techniques for predicting and assessing the efficacy of treatments for Type 1 diabetes. The award period runs from January 1, 2025 to December 31, 2028. As a public research university, the University of Virginia...
This Project Grant award of $155,500 from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 aims to accelerate the discovery of variant-specific therapies for ABCA3 deficiency, a rare genetic disorder causing neonatal respiratory failure and childhood interstitial lung disease. The grant supports the use of a human pulmonary epithelial cell line (A549) to conduct high-content analysis and high-throughput screening of FDA-approved compounds. The goal is to...
This $109,164 federal Project Grant award from the Department of Defense's Basic Scientific Research program (CFDA 12.431) to the Rector & Visitors of the University of Virginia supports research to optimize procedures for scent detection discrimination learning and generalization. The award period runs from January 15, 2025 to January 14, 2026. As a leading public research university, the University of Virginia has extensive expertise in supporting specialized research and technical...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $112,034 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the role of endothelial cell cycle control in embryonic arterial and venous specification. The research aims to rigorously define the cell cycle state of arterial and venous endothelial cells during vascular development and identify key...