Project Grant R03OD039968
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $729,587 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 21, 2025, with completion targeted for July 31, 2030. The project aims to develop a personalized, voxel-wise predictive model for identifying brain metastases risk in non-small cell lung cancer adenocarcinoma patients using multi-parametric magnetic resonance imaging. The...
- Federal Grant Award Summary The National Cancer Institute's Cancer Biology Research program (CFDA 93.396) awarded a $661,721 Project Grant to the University of California, San Diego, effective April 1, 2026, through March 31, 2031. This award supports systematic functional mapping and interrogation of oncogenic intrinsically disordered regions (IDRs) in cancer driver proteins. The research will utilize high-throughput functional screening technologies to perform domain and residue-level...
- Federal Grant Award Summary The University of California, San Francisco received a $451,000 Project Grant from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351) awarded July 1, 2026, with completion scheduled for June 30, 2028. The grant funds development of a novel chemical-genetic animal model for precise, programmable modulation of mammalian target of rapamycin (mTOR) signaling across multiple tissues and organs. This R21...
- Summary of Federal Project Grant Award The University of Texas Southwestern Medical Center received a $687,594 project grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. This award supports fundamental research on brain metastasis organotropism and therapy response in small cell lung cancer (SCLC), addressing the critical clinical need for more effective and less toxic treatment alternatives to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded University of California, San Diego a $410,115 project grant under the Cancer Biology Research program (CFDA 93.396) beginning August 1, 2025, with completion scheduled for July 31, 2027. This research initiative develops improved preclinical models for pancreatic ductal adenocarcinoma (PDAC) by incorporating three-dimensional high-density type I collagen into tumor modeling systems. The project addresses a...
- Federal Grant Award Summary The National Cancer Institute awarded a $410,933 Project Grant to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on March 18, 2026, with a completion date of February 29, 2028. This exploratory research grant supports the development of next-generation small interfering RNA (siRNA) therapeutics designed to enhance delivery of RNA interference treatments into metastatic castration-resistant prostate cancer (mCRPC)...
- Federal Grant Award Summary The University of California, San Diego received a $650,597 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, through March 31, 2031. This research initiative investigates the role of B-cells in durable complete responses to checkpoint blockade immunotherapy in head and neck squamous cell carcinoma (HNSCC). The project addresses a critical clinical gap, as while response rates to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of California, San Diego a $637,509 Project Grant on May 11, 2026, under the Cancer Biology Research program (CFDA 93.396) to support research investigating integrated G protein circuitry in cancer cell signaling autonomy through April 30, 2031. The research focuses on elucidating the molecular mechanisms by which cancer cells survive and proliferate in nutrient- and growth factor-limited...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded $847,780 to the University of California, Merced for a five-year Project Grant beginning September 1, 2025, and concluding May 31, 2030. The research investigates the fundamental mechanisms of stem cell regulation during tissue renewal and cancer development, with particular emphasis on understanding how stem cells survive...
- Federal Grant Award Summary The National Cancer Institute awarded UC San Diego a $771,811 Project Grant (CFDA 93.395: Cancer Treatment Research) effective June 1, 2026, through May 31, 2029, to identify small molecule activators of Type I Interferon (IFN-I) signaling for cancer treatment. The research project addresses a critical gap in cancer immunotherapy by developing inhibitors targeting USP18, a ubiquitin protease that negatively regulates IFN-I feedback signaling. Current clinical...
The University of California, San Diego received a $120,000 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to establish pre-clinical models for studying osimertinib resistance-mediated brain metastases in non-small cell lung cancer (NSCLC). The award, effective July 1, 2026 through June 30, 2028, supports the development of orthotopic NSCLC mouse models that replicate acquired osimertinib resistance and associated brain metastases, utilizing single-cell RNA sequencing to characterize molecular mechanisms. The project deliverables include two primary aims: (1) establishing and characterizing orthotopic NSCLC models of osimertinib resistance-mediated brain metastases using single-cell RNA sequencing, with comparative analysis against whole-genome sequencing data from NSCLC patients to identify common upregulated and downregulated pathways; and (2) characterizing circulating tumor cells (CTCs) from osimertinib-treated versus control NSCLC mouse models. These research models and associated characterization data will provide a preclinical platform for testing therapeutic strategies to overcome osimertinib resistance, addressing a critical gap in understanding heterogeneous cellular resistance mechanisms that cannot be explained by genetic mutations alone.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.0k | 6/24/26 |