Project Grant R01CA305983
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded UC San Diego a $661,721 Project Grant effective April 1, 2026, through March 31, 2031, under the Cancer Biology Research program (CFDA 93.396). This award supports research focused on systematic functional mapping and interrogation of intrinsically disordered regions (IDRs) in oncogenic proteins. The project will deliver comprehensive domain and residue-level perturbation screening of IDRs across approximately...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The University of California, San Diego received a $694,643 Project Grant from the National Cancer Institute (CFDA 93.395, Cancer Treatment Research) awarded on May 7, 2026, with an ultimate completion date of April 30, 2031. The grant supports research targeting the Hippo-YAP/TEAD signaling network in head and neck squamous cell carcinoma (HNSCC). This project addresses the significant clinical challenge of high mortality rates and treatment-related morbidity in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of California, San Francisco a $680,597 Project Grant under the Cancer Biology Research program (CFDA 93.396) on April 1, 2026, with an anticipated completion date of March 31, 2031. This five-year award funds genome-wide in vivo CRISPR screening research designed to identify G-protein-coupled receptor (GPCR) pathway targets that enhance chimeric antigen receptor T (CAR-T) cell therapies...
- Federal Grant Award Summary The University of California, Santa Barbara received a $402,400 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This award supports fundamental research investigating the structure-function relationship of the Wnt destruction complex (DC), a protein machine comprising disordered scaffold proteins APC and AXIN that regulate critical signaling interactions in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $144,981 Project Grant to the University of California, San Diego on September 3, 2025, under the Cancer Research Manpower program (CFDA 93.398). The grant funds a two-year research project through August 31, 2027, investigating the role of extrachromosomal DNA (ecDNA) in glioblastoma multiforme (GBM) heterogeneity and plasticity. The research deliverables include characterization of how ecDNA shapes the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $663,340 Project Grant to the University of California, Berkeley under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The award, made on August 27, 2025 with completion targeted for July 31, 2030, will fund investigations into how the local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer...
- Federal Grant Award Summary The National Cancer Institute awarded $411,206 to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on May 14, 2026, with a project completion date of April 30, 2028. This Project Grant supports the development of small molecule inhibitors targeting the proton-sensing G protein-coupled receptor GPR68 as a novel therapeutic approach for pancreatic ductal adenocarcinoma (PDAC). The research addresses a critical clinical...
- Federal Grant Award Summary The National Cancer Institute awarded a $403,686 Project Grant to the University of California, Irvine on March 19, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and validate innovative drug-diet combination therapies for advanced cancers. The research deliverables include the establishment of an unbiased, parallel genetic screening platform utilizing syngeneic orthotopic pancreatic ductal adenocarcinoma (PDAC) models to systematically...
- Federal Grant Award Summary The National Cancer Institute awarded UC San Diego a $410,933 Project Grant (Cancer Treatment Research, CFDA 93.395) effective March 18, 2026, with completion targeted for February 29, 2028. The award supports the development of next-generation small interfering RNA (siRNA) therapeutics designed to address metastatic castration-resistant prostate cancer (mCRPC), a lethal disease driven by genetically altered forms of the androgen receptor (AR). The research focuses on...
The National Cancer Institute (NCI) awarded a $637,509 Project Grant to the University of California, San Diego (UCSD) on May 11, 2026, under the Cancer Biology Research program (CFDA 93.396) to support a five-year research initiative extending through April 30, 2031. This award funds fundamental research investigating how cancer cells achieve signaling autonomy—the ability to sustain growth in nutrient- and growth factor-deprived environments—through rewiring of autocrine and paracrine "secrete-and-sense" circuits. The research specifically examines GIV (GA-Interacting Vesicle-Associated Protein) as a master regulator of cancer cell signaling autonomy, with particular focus on triple-negative breast cancers and estrogen receptor-positive breast cancers. The research deliverables encompass mechanistic investigations into G protein signaling integration, cancer stem cell biology, tumor progression pathways, and treatment resistance mechanisms. UCSD's research team will employ an integrated methodological approach combining animal and non-animal models (patient-derived organoids and tissue microarrays), synthetic biology tools with engineered cellular circuits, and quantitative live-cell imaging to characterize GIV-dependent signaling networks and their role in fostering cooperative growth among heterogeneous cancer cell populations. These research outputs are intended to advance fundamental understanding of cancer biology mechanisms with applications toward identifying novel therapeutic vulnerabilities and improving cancer prevention, detection, diagnosis, and treatment strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $637.5k | 5/11/26 |