This Project Grant award of $1 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to identify novel genetic predisposition genes associated with orofacial clefts. The research team at Mayo Clinic will leverage large public DNA sequencing and gene expression datasets to perform discovery, validation, and combined analyses, with the goal of facilitating early diagnosis, risk...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
This federal Project Grant award of $295,856.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award will fund research to identify rare genetic variants associated with orofacial clefts, which are the most common birth defects affecting the head and neck. The key objectives are (1) to identify craniofacial genes with rare deleterious variants, and (2) to identify craniofacial...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $1,849,232.90 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to identify the cellular and molecular identity of genes and pathways defining dental mesenchymal cell differentiation and fate early in tooth development. The goal is to harness this information to develop potential...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,325,889 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Southern California on September 19, 2024. This grant, titled "Regulating Skeletal Connectivity in Craniofacial Development and Disease," will support a comprehensive and forward-thinking research program led by Dr. Amy Merrill that investigates the craniofacial skeleton as a multi-tissue...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $714,711 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, which commenced on July 1, 2025, aims to investigate mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth following radiation therapy. The research team developed a scalable gene targeting system to screen over...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research at Stanford University to integrate 4D Nucleome (4DN) data with Genotype-Tissue Expression (GTEx) and Undiagnosed Diseases Network (UDN) transcriptomics data. The goal is to leverage 3D genomic information to identify functional rare variants that impact gene expression and contribute to rare diseases. The $1...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This federal Project Grant award of $503,648 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the genetic mechanisms driving the specification of oral/dental and skin lineages in the mandibular ectoderm. The research aims to determine how transcription factor interactions regulate these epithelial patterning processes, including identifying the chromatin-level regulation...
This federal Project Grant award of $429,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to determine the functional roles and mechanisms of the human microbiome and metabolome in the pathogenesis of oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to 1) define OSCC-associated metagenomic and...