Project Grant R03NS148802
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a Project Grant totaling $601,750 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective June 12, 2026, with a completion date of March 31, 2031. The University of Michigan will develop and apply VISTA-FISH (Video Imaging with Spatial-Temporal Analysis by FISH), an innovative technology...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $659,325 to the Regents of the University of Michigan on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This Project Grant, extending through June 30, 2029, funds research investigating neuro-immune mechanisms in mutant isocitrate dehydrogenase 1 (IDH1) gliomas. The research aims to identify how mutant IDH1...
- Federal Grant Award Summary The University of Michigan received a $357,191 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 7, 2025, with completion by July 31, 2030. This research initiative investigates seizure-induced remodeling of cholinergic networks in Dravet syndrome, a severe developmental and epileptic...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a Project Grant totaling $602,506 on June 12, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research focused on characterizing somatic numtogenesis—the integration of mitochondrial DNA fragments into nuclear DNA—with particular emphasis on studying nuclear...
- Federal Project Grant Award Summary The University of Michigan received a $556,525 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2025 through April 30, 2030. The award supports the development and dissemination of artifact-free micro-light-emitting diode (micro-LED) optoelectrode platforms designed to advance neural circuit...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $373,200 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025, through June 30, 2030. The award funds basic neuroscience research investigating the role of messenger RNA (mRNA) nuclear localization in circadian rhythm regulation. Specifically, the...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $443,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective June 1, 2026 through May 31, 2028. The award funds research to define the dominant-negative effects of neuropathy-associated transfer RNA (tRNA) synthetase variants. The research team will employ a...
- Federal Grant Award Summary The University of Michigan received a $3,977,894 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded August 1, 2025, with completion targeted for July 31, 2028. This grant funds development of a scalable high-plex pipeline for whole-brain proteomics profiling that addresses critical gaps in molecular characterization of distinct brain cell types. The project delivers a comprehensive...
- Federal Project Grant Award Summary The University of Michigan was awarded $128,358.00 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for a project commencing February 16, 2026, with completion targeted for January 31, 2028. The research project investigates cholinergic neurotransmitter changes and their associations with sleep disturbances across the Lewy body...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $429,000 to the University of Michigan's Office of Research and Sponsored Projects, effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project investigates the mechanism of Notch inhibition resistance in glioblastoma (GBM) stem cells to develop novel...
The University of Michigan's Regents, through its Office of Research and Sponsored Projects, received a $146,630 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, obligated on June 15, 2026 with a completion date of May 31, 2027, funds research aimed at identifying the histone and non-histone substrates of the neuron-specific lysine-specific demethylase 1 (LSD1)-PHF21A chromatin regulator complex. The research deliverables will employ chromatin biochemistry and proteome-wide methylation analysis techniques to determine the bona fide substrates of this neuronal complex. The project builds upon prior discoveries that neuron-specific splicing variants of LSD1 and PHF21A impair nucleosome binding and reduce histone demethylation activity differently than previously reported mechanisms. By clarifying the substrate specificity of this neuron-specific complex, the research is expected to advance understanding of chromatin regulation mechanisms unique to neurons and inform therapeutic strategies for neurodevelopmental disorders characterized by chromatin dysregulation, including intellectual disabilities, autism spectrum disorder, and schizophrenia.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $146.6k | 6/16/26 |