Project Grant R37NS144573
- This federal Project Grant award of $656,879.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research at the University of Texas Southwestern Medical Center (UT Southwestern) to study the mechanisms by which isocitrate dehydrogenase (IDH) mutations contribute to the initiation and progression of lower grade gliomas. The research...
- This federal Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to explore the mechanism of Notch inhibition resistance in glioblastoma (GBM) cancer stem-like cells. The goal is to develop novel therapies for this deadly brain cancer. The research project, led by the Regents of the University of Michigan, will identify GBM...
- The Project Grant award of $412,499.00 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), supports research on the molecular mechanisms of mutant IDH inhibition and DNA damage in IDH-mutant glioma. The project aims to use a newly developed genetically engineered mouse model of IDH-mutant grade 3 astrocytoma to understand...
- This federal Project Grant award of $460,940 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the University of Texas MD Anderson Cancer Center to investigate how genetic risk factors for glioma, a type of brain cancer, impact neurodevelopmental processes and potentially promote tumor formation. The research leverages human...
- This Project Grant award of $687,279 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to uncover the effects of standard-of-care therapy on immune and neoplastic cell population dynamics in pre-clinical mouse models of glioblastoma (GBM) and analysis of human GBM samples. The goal is to identify tumor microenvironment areas of therapeutic...
- This federal Project Grant award of $131,360 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research at the University of New Haven to characterize the long non-coding RNA GIHCG and assess its potential as a therapeutic target for glioblastoma, the most aggressive form of brain cancer. The 4-year project aims to use CRISPR/Cas9 gene editing to...
- This federal Project Grant award of $2,467,799 from the National Cancer Institute, under the Cancer Biology Research program (CFDA 93.396), is supporting research at Washington University to understand the role of the myeloid cell metabolic enzyme wild-type IDH1 (WT-IDH1) in glioblastoma. The research aims to investigate how targeting WT-IDH1 in tumor-associated myeloid cells can reprogram the tumor microenvironment to enhance anti-tumor immune responses and slow glioblastoma growth. This 4-year...
- This federal Project Grant award of $610,554.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to mechanistically link and leverage the interrelated findings on tumor-induced alterations in peritumoral neuronal mTOR and GABAergic signaling. The research aims to understand how these alterations contribute to both tumor-associated seizures and...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports research to define the role of IKBA deficiency in aberrant neural progenitor cell lineage commitment and gliomagenesis. The $599,005 award to the University of Miami, with a project period from August 2025 to July 2030, will investigate how IKBA regulates Polycomb Repressive...
- This federal Project Grant award of $414,953 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is focused on understanding the role of inflammasomes, which are protein complexes that induce inflammatory responses, in driving sexual dimorphism in glioma therapies. The key objectives are to determine whether inhibiting the NLRP3 inflammasome can overcome...
This federal Project Grant award for $659,325.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the role of mutant IDH1 in glioma pathophysiology and immune response mechanisms. The research will use a novel murine glioma model developed by incorporating genetic lesions into neural progenitor cells using the Sleeping Beauty transposase system. Key objectives include profiling gene expression changes, signaling pathways, and immune response mechanisms in mutant IDH1 gliomas compared to wild-type. This research aims to reveal therapeutic interventions for mutant IDH1 gliomas and suggest approaches for wild-type IDH1 therapeutics. The award period runs from August 1, 2025 to June 30, 2029 and is funded through the University of Michigan's Office of Research and Sponsored Projects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $659.3k | 7/30/25 |