Project Grant K99NS146570
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Michigan a $107,097 Project Grant effective September 16, 2025, through June 30, 2027, under the Aging Research program (CFDA 93.866). This research project investigates the relationship between sleep disturbances and age-related memory loss by examining how sleep deprivation alters the activity and connectivity of somatostatin-expressing inhibitory interneurons in the hippocampus. The research...
- Federal Grant Award Summary The University of Michigan received a $633,146 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 4, 2025, with completion targeted for July 31, 2030. The project addresses vascular cognitive impairment and dementia (VCID) following stroke by investigating modifiable risk factors and prevention...
- Federal Grant Award Summary The University of Michigan received a $10.4 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 1, 2025, with completion scheduled for July 31, 2029. This research initiative represents the first study evaluating personalized brain stimulation as a treatment for Posterior Cortical Atrophy (PCA), a neurodegenerative condition most commonly caused by Alzheimer's disease. The primary deliverable...
- Federal Project Grant Award Summary The University of Michigan received a $556,525 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2025 through April 30, 2030. The award supports the development and dissemination of artifact-free micro-light-emitting diode (micro-LED) optoelectrode platforms designed to advance neural circuit...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $373,200 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025, through June 30, 2030. The award funds basic neuroscience research investigating the role of messenger RNA (mRNA) nuclear localization in circadian rhythm regulation. Specifically, the...
- Federal Grant Award Summary The University of Michigan received a Project Grant award of $130,230 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 15, 2025, through April 30, 2030. The award funds the Neuroscience Undergraduate Research Opportunities (NURO) program, which delivers an integrated year-long research training initiative combining a...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $357,191 Project Grant on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year award, extending through July 31, 2030, supports fundamental research investigating seizure-induced remodeling of cholinergic neural networks in Dravet syndrome, a severe...
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Michigan a $156,000 Project Grant under the Aging Research program (CFDA 93.866) to conduct a structural neuroimaging study examining the relationship between mild behavioral impairment (MBI) and brain network changes in early-stage Alzheimer's disease and related dementias (ADRD). Awarded on August 5, 2025, with completion targeted for April 30, 2027, the project will deliver a network-level...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,234,905.00 in funding to The University of Iowa to support research aimed at understanding the underlying mechanisms responsible for cognitive fluctuations in Lewy body disorders (LBD). The project will use mouse models to evaluate how the accumulation of...
- Federal Project Grant Award Summary Virginia Commonwealth University received $732,992 in Project Grant funding from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded June 20, 2025, with completion targeted for March 31, 2030. The funded research will elucidate the role of central cholinergic degeneration in cognitive fluctuations associated with Lewy body...
The University of Michigan was awarded $128,358 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on February 16, 2026, with a completion date of January 31, 2028. This Project Grant supports investigator-initiated research examining cholinergic neurochemical changes and their associations with sleep disturbances across the Lewy Body Disease (LBD) spectrum, which includes Parkinson's Disease and Dementia with Lewy Bodies. The research aims to identify new biomarkers and potential therapeutic targets by studying how alterations in cholinergic neurotransmission—specifically changes in acetylcholine availability—may disrupt the sleep-wake cycle and contribute to REM Sleep Behavior Disorder (RBD), an early clinical manifestation of LBD. The project utilizes advanced neuroimaging technology with [18F]-FEOBV positron emission tomography (PET), which selectively binds to the vesicular acetylcholine transporter, combined with wearable at-home sleep recording devices and validated clinical assessments to quantify sleep architecture and cholinergic alterations. This ecological approach to investigating sleep biomarkers represents a translational research effort that bridges preliminary findings in Parkinson's Disease patients toward a broader understanding of early LBD pathophysiology. The research is conducted at the University of Michigan's Ann Arbor campus and is expected to generate evidence supporting the development of cholinergic-targeted interventions for sleep dysregulation in neurodegenerative diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.4k | 2/16/26 |