Project Grant R21AG097123
- This federal Project Grant award for $694,824 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to investigate the relationship between the gut microbiome and age-related joint degeneration, or osteoarthritis (OA). The research, conducted by the University of California, San Francisco (UCSF), will focus on examining how changes in the gut microbiome during aging may influence the development of spontaneous, age-related joint degradation. Key...
- This federal Project Grant award of $856,580 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 5-year research project to investigate the relationship between the gut microbiome and Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project aims to elucidate the microbial origins of AD/ADRD in the Latino population, which has double the risk of AD/ADRD compared to non-Latino whites. Key...
- This federal Project Grant award of $3,251,767.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University supports research to understand how indoles from commensal gut bacteria can promote mobility and healthspan in aging animals, including mice, fruit flies, and nematodes. The research aims to elucidate the mechanisms by which indoles, acting through the aryl hydrocarbon receptor, can limit sarcopenia and preserve muscle function and mitochondrial health...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,931.00 to the University of Colorado-Denver to characterize how specialized microbial metabolites mediate interactions within the human microbiome. The research aims to elucidate the role of these metabolites in enabling microbial communities to resist antimicrobial therapies, with the goal of improving...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- The University of Chicago received a $486,611 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) with a project period from September 30, 2023 to September 29, 2025. The purpose of this grant is to conduct a study examining the effect of cocoa flavanols on the gut microbiome and functional performance in individuals with peripheral artery disease (PAD). The study aims to: 1) determine if baseline gut microbial diversity and composition are...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- This Project Grant award of $1,025,888 from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), supports research by the University of Oregon. The project aims to establish methods for measuring and documenting variation in the mitochondrial stimulatory activity of human gut microbiomes, as well as explore relationships between exercise-associated microbiome changes and...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the relationship between HIV infection, aging, and cognitive decline. The $629,712 award to SRI International aims to leverage magnetic resonance imaging (MRI) and biomarker analysis to better understand how the brain's waste clearance system, known as the glymphatic system, may contribute to heightened risk of cognitive impairment in aging...
This Project Grant award of $429,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Colorado-Denver aims to investigate the relationship between gut microbiota dynamics, exercise, and physical function among older adults with HIV. The research project will examine how exercise-induced changes in the gut microbiome may contribute to improvements in physical function for this population, which has been observed to experience impairments in physical function measures. Key areas of focus include understanding the role of the gut-microbiome-exercise axis, the impact of HIV-associated gastrointestinal disruption, and the potential use of biomarkers like intestinal fatty acid binding protein and myostatin to track outcomes. The award period runs from August 15, 2025 to July 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 8/12/25 |