Project Grant R03HD121464
- Federal Project Grant Summary The University of Missouri System received a $411,539 project grant awarded May 15, 2026, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). This research initiative focuses on investigating the functional significance of extracellular vesicles (EVs) from the female reproductive tract during early pregnancy and their role in embryo-maternal communication....
- Federal Project Grant Award Summary The University of Missouri System received a $413,118 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This five-year award supports fundamental research investigating organelle transport and organization mechanisms in mammalian oogenesis, with specific focus on how primary oocytes are determined during...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded Magee-Womens Research Institute and Foundation a $595,864 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of hyaluronan in primordial germ cell (PGC) development and ovarian reserve establishment. The award, issued August 15, 2025, with a completion date of May 31, 2030, supports basic...
- Federal Grant Award Summary The University of Missouri System received a $166,310 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period September 1, 2025 through August 31, 2027. The research project, titled "Intergenerational Socioeconomic and Health Effects of Family Support Programs," examines the long-term impacts of welfare program withdrawal...
- Federal Grant Award Summary The University of Michigan received a $390,504 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2026 through February 28, 2031. This award funds research to advance understanding of human primordial germ cell (hPGC) differentiation from human pluripotent stem cells, with applications toward in vitro gametogenesis and...
- Federal Project Grant Summary The University of Kentucky Research Foundation received a $665,122 Project Grant award dated July 15, 2025, from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research investigating the role of glucocorticoid receptor (GR) in ovarian function, with a completion date of May 31, 2030. The research addresses a critical gap in understanding ovarian...
- Federal Project Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded $419,014 to the University of Kentucky Research Foundation beginning September 1, 2025, and concluding August 31, 2027. This project grant funds investigator-initiated biomedical research designed to advance understanding of reproductive health and female fertility outcomes....
- Federal Project Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $426,250 Project Grant award dated August 6, 2025, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research through July 31, 2027, investigating the role of Protein Arginine Methyltransferase 1 (PRMT1) in regulating trophoblast development and...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a Project Grant of $125,142 under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective June 1, 2026, through May 31, 2028. This award funds research investigating the impact of bacterial vaginosis (BV) toxins on sperm function and fertility. The research will elucidate the molecular mechanisms by which BV-associated toxins,...
- Federal Project Grant Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $425,628 project grant to the Regents of the University of California at Riverside on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (through July 31, 2027) investigating the molecular mechanisms by which mutations in the Fragile X Messenger Ribonuclein 1...
Federal Project Grant Award Summary The University of Missouri System received a $153,675 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded May 15, 2026, with completion targeted for April 30, 2028. This research initiative investigates progesterone receptor (PGR) signaling in oviductal ciliated cells and its role in maintaining reproductive longevity. The project addresses a critical gap in reproductive aging research by examining how hormonal signaling in extra-ovarian tissues contributes to fertility maintenance across the lifespan. The research deliverables encompass two primary aims: (1) determining how loss of PGR in ciliated epithelial cells impairs epithelial function and reproductive longevity through analysis of ciliary beat frequency, particle tracking, epithelial morphology, and in vivo oocyte pickup capacity; and (2) defining molecular mechanisms by which PGR maintains ciliated epithelial cell identity and homeostasis using single-cell RNA sequencing and transcriptional profiling to identify progesterone-regulated pathways. These research activities are expected to yield novel insights into unexplained infertility and age-associated reproductive decline, advancing the scientific understanding of reproductive aging mechanisms beyond traditional ovarian function perspectives.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $153.7k | 5/12/26 |