Project Grant K99HL177341
- This $721,826 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify molecular mechanisms regulating alveolar matrix fibroblast function and their role in supporting vascular capillary formation. The research is being conducted by Children's Hospital Medical Center in Cincinnati, Ohio to advance the understanding of alveolar septation and septal wall maturation, which is...
- This federal Project Grant award of $123,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the Hedgehog signaling pathway in regulating progenitor cell differentiation during lung development and its potential contribution to lung diseases like COPD and IPF. The project will analyze existing single-cell data from mouse and human lungs to: 1) decipher the temporal control of Hedgehog signaling in regulating...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $106,391 to the University of Colorado-Denver to investigate the role of developmental dysanapsis in lung development over the lifespan in an experimental bronchopulmonary dysplasia (BPD) model. The research aims to determine whether intra-amniotic endotoxin causes persistent dysanaptic growth of the airways, distal parenchyma, and vasculature in BPD, and...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $594,583 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The grant supports research to investigate the mechanisms regulating the development, expansion, and decline of neonatal lung myofibroblasts and their role in alveologenesis. Key objectives include utilizing a novel murine model to study myofibroblast lineage, characterize...
- This federal Project Grant award, titled "Regulation of Primary and Secondary Alveologenesis by FGF Signaling Pathways", was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $740,317 award supports research conducted by The Washington University in St. Louis, Missouri to advance scientific understanding of alveolar development and lung regeneration. The research aims to investigate the mechanisms that regulate...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $166,395 to Columbia University to conduct a 5-year research project on the impact of hyperoxia (excess oxygen) on the function of respiratory progenitor cells in neonates. The project aims to develop a better understanding of the mechanisms by which post-natal lung development occurs in the face of injurious agents like oxygen...
- This federal Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $107,752 to Duke University to investigate the mechanisms of lung fibrosis. The research aims to evaluate epithelial cell-fibroblast interactions contributing to fibroblast activation through the CTHRC1-TGFβ signaling pathway, in the context of bronchiolitis obliterans and idiopathic pulmonary fibrosis. The 2-year project leverages Duke's...
- This federal Project Grant award for $637,913, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research by the University of Southern California (USC) to investigate the role of "transitional alveolar epithelial cells" in lung development and regeneration. The goal is to better understand the mechanisms underlying the alveolar epithelial cell differentiation process during normal lung development, as...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $586,021 to The Medical College of Wisconsin, Inc. to establish patient-reported outcome measures that refine neonatal risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The goal is to identify hospital-to-home transition strategies that reduce post-prematurity respiratory...
- This $173,259.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA Program: Cardiovascular Diseases Research) supports research to investigate the role of the transcription factor KLF6 in lung development and respiratory health. The primary objectives are to: 1) delineate the mechanism of KLF6 function in prenatal lung growth and branching morphogenesis, and 2) determine the KLF6-regulated target genes and signaling pathways involved in postnatal alveolar epithelial cell...
This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the role of the hedgehog pathway and primary cilia axis in human lung alveologenesis and diseases such as bronchopulmonary dysplasia (BPD). The $156,168 grant awarded to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center will fund a 2-year study examining the cellular and molecular mechanisms underlying alveolar formation, with the goal of improving understanding of BPD and other lung disorders. The research aims to elucidate how hedgehog signaling and primary cilia regulate alveolar progenitor cell interactions and differentiation during lung development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.2k | 8/23/25 |