This Project Grant award, valued at $423,036.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to better understand the molecular mechanisms underlying the biogenesis and function of pachytene piRNAs, a unique class of small RNAs found in mammalian germ cells. The research aims to elucidate how regulatory motifs direct piwi proteins to engage in piRNA biogenesis,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research provides $1,279,780.00 to Wayne State University to study the mechanisms of the MEIG1 complex in mammalian spermiogenesis and fertilization. The key objectives are to: Dissect the motor-based complex in the manchette and its role in sperm formation Establish an in vivo system to investigate protein...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $407,592 to the Whitehead Institute for Biomedical Research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The research aims to: (A) discover mechanisms that repress the somatic program to allow the primordial germ cell (PGC) program to...
This Project Grant award, valued at $107,458, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the mechanisms of double strand break repair in fetal male germ cells, which are precursors to spermatogonial stem cells that supply sperm throughout a male's reproductive lifespan. The research, to be conducted at Duke...
This Project Grant award of $128,214.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how parental CENP-A protein levels equalize during the first cell cycle of mammalian embryogenesis. The award aims to advance understanding of the molecular origins of acquired aneuploidy, which can occur during early embryonic cell...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,188,266 to the Icahn School of Medicine at Mount Sinai to conduct research on the regulation of the germ cell-to-maternal transition. The funded project aims to uncover how this critical developmental transition is regulated, focusing on understanding the changes in gene expression, targeting of germ cell-specific genes for...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $202,864 to the University of Wisconsin - Madison to investigate the role of histone demethylases KDM3A and KDM3B in primordial germ cell (PGC) development. The research aims to elucidate how the removal of repressive epigenetic modifications, such as H3K9me2, impacts PGC specification and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $148,000.00 to the University of Southern Mississippi to investigate the potential molecular mechanisms linking infertility and cancer. The primary objectives are to (1) use humanized yeast to assess the impact of 30 cancer-associated protein phosphatase 1 (PP1) variants on...
The National Institute of Child Health and Human Development (NICHD) awarded a $225,324 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Duke University to conduct research on the role of mitochondrial specialization in early embryonic development. The research, led by the Sherwood Lab, will utilize a newly developed in vivo toolkit in C. elegans to investigate how the mitochondrial electron transport chain (ETC) is regulated to meet the varying energetic...
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...