This $147,087 federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate how the apical extracellular matrix (AECM) regulates the formation and dimensions of tubular organs such as the kidney, lungs, and digestive system. The research, conducted at Louisiana State University, will investigate the role of specific AECM components like zona pellucida proteins and mucins, as well as the mechanisms by which the enzyme PAPSS modifies the AECM to control organ tube size. The project aims to provide broader insights into how epithelial cells generate and modulate their extracellular environment to influence tissue morphogenesis, with potential applicability to the development and function of human organs. The award period runs from May 1, 2025 to April 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $147.1k | 4/16/25 |