Project Grant R03DE034500
- This Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is funding research to investigate the role of oral microbially-induced exosomes in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The $550,627 award, with a project period from January 1, 2025 to November 30, 2029, is being provided to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $198,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Pennsylvania State University (Penn State) to conduct research on integrating population-wide oral microbiome data to better understand health differences in the United States. The project, which will run from July 1, 2025 to June 30, 2027, aims to disentangle how an individual's background and socioeconomic factors...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $226,500 to investigate how oral bacterial pathogens affect aging-associated immune responses and whether inhibition of the inflammatory marker CD38 can alleviate inflammatory bone loss and aging-associated immune responses induced by oral pathogens. The project, conducted by the Medical University of South Carolina, aims...
- The Project Grant award of $205,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The key products and services to be delivered under this award include: Collecting oral samples (supragingival plaque and saliva) and blood samples...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- This $499,996 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will fund a research project conducted by The Pennsylvania State University to reconstruct the history of the human oral microbiome on a global scale. The project aims to understand the evolutionary mechanisms that drive changes in human microbiome diversity over time, particularly in response to shifts in geography, environment, and culture. By analyzing bacteria...
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $673,091 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Pittsburgh. The grant, which runs from August 14, 2025 to May 31, 2028, aims to advance the genomics knowledge base for oral diseases, focusing on dental caries and periodontitis. Key activities include performing the largest genome-wide association scans of these conditions, developing...
- This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $12,591,952 in funding to conduct a randomized, double-blind, placebo-controlled study of the drug LHP588 in subjects with Porphyromonas gingivalis (P. gingivalis)-positive Alzheimer's disease (AD). The study aims to investigate whether LHP588, a brain-penetrant gingipain inhibitor, can mitigate AD-associated neuropathological features by targeting the bacterial contribution to the...
- This federal Project Grant award for $331,999 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to determine the causal relationship between poor oral health and heart disease. The primary awardee, Lehigh University, will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model to identify genetic risk factors for poor oral health. They will then leverage this to...
This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), funds research to investigate the association between the oral microbiome and biomarkers of Alzheimer's disease and related dementias (ADRD), as well as mid-life cognitive function. The $332,787 award, granted on August 14, 2025, will leverage data from the High School & Beyond (HS & B:80) cohort study to analyze oral microbiota assessments and blood-based ADRD biomarkers in over 4,220 participants. The project aims to address limitations in prior research by studying a large, diverse sample and examining cognitive function prior to ADRD onset. The research could provide insights into the potential role of the oral microbiome in ADRD pathology and cognitive health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $332.8k | 8/14/25 |