This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The $794,341 award, effective from January 1, 2025 through December 31, 2029, will be conducted by the University of Illinois in Chicago. The research aims to leverage experimental mouse models, molecular characterization of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University will provide $819,054 to conduct a multifaceted study examining the link between oral health and different subtypes of dementia, including Alzheimer's disease and vascular dementia. The research will analyze data from large population-based datasets to investigate the biological pathways and social determinants underlying this relationship. A sub-award of $263,002 will go...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cell-type specific impacts of Alzheimer's disease (AD) pathology within the medial temporal lobe. The $103,304 award, effective August 1, 2024 through July 31, 2025, will utilize advanced viral tracing methods and microscopy imaging to identify and reconstruct 3D entorhinal cortex-CA1 neuron circuits that are susceptible to AD pathology propagation. After...
This federal Project Grant award, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports a study to investigate the role of the gut microbiome in the risk of Alzheimer's disease and related dementias (AD/ADRD) among the Latino population. The $856,580 award, with a period of performance from February 1, 2025 to January 31, 2030, will fund the collection and analysis of gut microbiome and blood metabolomic data from participants in the Hispanic Community Health...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,750 to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of oral spirochetes in promoting neuroinflammation and dysfunction. The key objectives are to: 1) Characterize the ability of oral spirochetes to induce blood-brain barrier dysfunction, and 2) Assess the capacity of oral spirochetes to drive an inflammatory response in glial cells of the...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,357 in funding to the Research Foundation of the City University of New York (RFCUNY) for research to elucidate molecular mechanisms underlying the neurodegenerative reprogramming of microglia in Alzheimer's disease. The key objectives are to determine how the integrated stress response pathway triggers chromatin remodeling in microglia, examine how this exacerbates their stressed...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...