Project Grant R01DE034447
Award Date
4/10/25
Completion Date
1/31/30
Dollars Obligated
$690K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $109,548 Project Grant to the University of Pittsburgh under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research to investigate the interactions between phosphorylated amelogenin and acid phosphatase 4 (ACP4) expression, which are critical to proper enamel formation. The research will utilize single-cell RNA sequencing, RT-qPCR, Western blot analysis, immunohistochemistry, in situ...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides USD 249,000 to the Regents of the University of Michigan for a project investigating the ameloblast-specific mineral ribbon attachment and elongation complex in enamel formation. The key objectives of this 3-year project are to: 1) identify the critical components of the ameloblast-specific mineral ribbon...
This Project Grant award of $593,468.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports research to investigate the role of the TRPS1 transcription factor in regulating dentinogenesis and its impact on dental caries susceptibility. The research aims to determine how TRPS1 deficiency in odontoblasts affects the micro- and nanomorphology of dentin and enamel, the formation of...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate a novel regulator, DIN, that governs the regenerative capacity of murine teeth. The $346,938 award, with a performance period from September 12, 2024 to August 31, 2029, aims to determine DIN's role in regulating mesenchymal stem cell (MSC) homeostasis during tissue turnover and...
This $152,680 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) supports research to investigate the mechanisms of pulpitis (inflammation of the dental pulp) associated with molar hypomineralization (MH), a prevalent enamel defect affecting 15% of children worldwide. The key objectives are to: 1) Examine the role of sensory neuron activation in pulpal inflammation using...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
This $924,616.45 federal Project Grant award was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research to identify the cellular and molecular mechanisms controlling tooth development, with the goal of developing potential therapies for dentin regeneration. The awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will leverage its...
This National Institute of Dental and Craniofacial Research (NIDCR) Oral Diseases and Disorders Research (CFDA 93.121) Project Grant award to East Carolina University (ECU) aims to develop innovative dental materials that can inhibit the formation of harmful bacterial biofilms while preserving beneficial oral bacteria. The $164,255 grant will fund research to synthesize a new antimicrobial agent, formulate it into methacrylate-based self-etch adhesive (SEA) dental materials, and evaluate the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $441,500 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to the University of Colorado-Denver to develop uniquely high conversion and mechanically robust composite restorative materials for improved dental applications. The award aims to investigate the structure-property relationships and mechanisms that enable these novel polymer composites to achieve exceptional strength, toughness, and wear...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $443,576 to the University of Washington to develop bioengineered 3D tooth germs for tooth regeneration in vitro and in vivo. The key objectives are to: 1) investigate how material composition and mechanical properties regulate stem cell renewal and support long-term growth of odontogenic epithelial stem cells...