Project Grant R03AR085214
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), will support research to investigate the role of the Runx2 and Runx3 transcription factors in regulating the development and differentiation of growth plate chondrocytes. The $221,484 award, with a project period from July 1, 2025 to June 30, 2028, will be conducted by the Children's...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to understand and address growth plate dysfunction in pediatric skeletal disorders. The $378,250 award to The Children's Hospital of Philadelphia Research Institute will fund a 6-year project to assess growth plate dysfunction, delineate the underlying cellular mechanisms,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $676,841 Project Grant titled "LEVERAGING HUMAN MUSCULOSKELETAL DEVELOPMENT TO IDENTIFY CAUSAL DISEASE VARIANTS" to President and Fellows of Harvard College. The award period runs from August 1, 2025 to July 31, 2030 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The objective of the project is to conduct targeted functional genomic studies...
- This $674,620 federal Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The grant funds research to investigate the genetic and developmental basis for coordinated growth of limb structures. The researchers used genetic screens in zebrafish to identify potassium channels KCNH2...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Broad Institute, Inc. to transform the Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase. The project aims to integrate diverse 'omics datasets curated by musculoskeletal research experts, process the data through advanced genetic and genomic analysis...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- The University of Pennsylvania was awarded a $459,820 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant will support research into the role of mitochondrial respiration and bioenergetic metabolism in the regulation and development of growth plate chondrocytes, which are central to bone formation. The research aims to improve...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- This federal Project Grant award of $1,948,116.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research into post-transcriptional regulation of gene expression during bone regeneration, with a focus on understanding the expression patterns and biological functions of the protein Proteoglycan 4 (PRG4) during fracture healing. The research...
- This Project Grant award, valued at $359,133.00, was issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports the generation of new genetic tools to enable more targeted and specific analysis of tendon and musculoskeletal tissues in mice. The goal is to develop constitutive and inducible FLP alleles that can be used in combination with existing...
This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel modulators of limb development and chondrocyte maturation. The goal is to elucidate the genetic pathways directing chondrocyte maturation in order to better understand and potentially develop treatments for skeletal dysplasia and extreme short stature conditions resulting from growth plate disorders. The award period runs from August 2025 through July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $177.0k | 8/19/25 |