Project Grant R01AR083978
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Broad Institute, Inc. to transform the Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase. The project aims to integrate diverse 'omics datasets curated by musculoskeletal research experts, process the data through advanced genetic and genomic analysis...
- This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $439,791 Project Grant to The University of Texas Southwestern Medical Center on March 1, 2025 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports research to investigate the molecular mechanisms of myoblast fusion, which is essential for skeletal muscle development and regeneration. The research aims to understand the cellular and...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $413,655 on August 1, 2025 to Arizona State University (ASU) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to develop biomaterials with temporal control of proteins, such as Bone Morphogenetic Proteins (BMPs), to enhance bone repair. The research aims to mimic natural extracellular matrix interactions and synergies...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- This $250,396 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify differences in DNA regulatory elements that control gene expression in skin cells from individuals of different ancestral backgrounds. The research team at the Icahn School of Medicine at Mount Sinai will utilize advanced genomic techniques, including...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Vanderbilt University a Project Grant of $336,630 on August 15, 2025 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant will support the Integrated Training in Bone Biology, Biomechanics, and Regeneration (IT3BR) program, which aims to train the next generation of scientists in multidisciplinary musculoskeletal research focused on bone biology,...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $198,263 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Board of Regents of the University of Nebraska. The research project aims to investigate the role of the protein Mitsugumin 53 (MG53) in preventing muscle atrophy during periods of disuse, which can contribute to age-related sarcopenia and frailty. The research will explore how...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- This new $298,166 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will support the Rheumatology Research Training Program at Northwestern University's Feinberg School of Medicine over a 5-year period from September 1, 2025 to August 31, 2030. The program aims to develop a diverse pool of well-trained scientists with the skills to conduct rigorous and reproducible research on the causes, treatment, and prevention of arthritis,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $676,841 Project Grant titled "LEVERAGING HUMAN MUSCULOSKELETAL DEVELOPMENT TO IDENTIFY CAUSAL DISEASE VARIANTS" to President and Fellows of Harvard College. The award period runs from August 1, 2025 to July 31, 2030 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The objective of the project is to conduct targeted functional genomic studies on the human fetal skeleton, using single cell multi-omics and spatial transcriptomics techniques, to generate transcriptomic and epigenomic maps of all major joints in the post-cranial body. These data will then be intersected with human disease-causing genetic variation from genome-wide association studies to identify causal variants that impact gene expression and skeletal morphology. This work aims to address a major gap in knowledge about the genetic and regulatory mechanisms controlling differences in skeletal development between humans and mice, which has important implications for understanding common skeletal diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $676.8k | 8/1/25 |