This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $735,372 to Brigham & Women's Hospital Inc. to conduct research on T cell expression of inflammatory chemokine receptors in chronic autoimmune conditions. The research aims to identify transcription factors and cytokines that regulate the expression of key chemokine receptors, such as CCR2, CCR5, and CXCR6, which are involved in the migration of T cells to inflamed tissues in conditions like rheumatoid arthritis. The project will utilize CRISPR screens, cytokine stimulation assays, epigenetic analyses, spatial transcriptomics, and human synovial organoids to better understand the underlying mechanisms controlling this migratory program in T cells. The goal is to reveal dominant pathways that could lead to new strategies to therapeutically interfere with pathologic T cell migration in chronic autoimmune diseases. The award period runs from May 15, 2025, to February 28, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $735.4k | 5/15/25 |