Project Grant R01AR084627

Award Date 5/15/25
Completion Date 2/28/30
Dollars Obligated $735K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $139,895 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. in Boston, MA. The grant aims to investigate the role of "trained immunity" in linking inflammatory arthritis to the development of cardiovascular disease. Specifically, the research will test the hypothesis that inflammatory responses in...
This federal Project Grant award of $170,101 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize the spatial heterogeneity of synovial inflammation in rheumatoid arthritis (RA). The principal investigator at Brigham & Women's Hospital Inc. will use advanced statistical techniques and artificial intelligence to identify the spatial...
This federal Project Grant award of $529,616 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the role of Notch signaling in driving fibrogenesis and treatment failure in rheumatoid arthritis (RA). The key objectives are to: 1) define the Notch-driven fibrogenic transcriptional program in synovial fibroblasts, 2) determine the impact of this...
This $366,797 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research on the mechanisms of reverse transendothelial migration of neutrophils in the resolution of inflammation. The project, conducted by the University of Missouri System, will investigate how neutrophils that enter infected or damaged tissues can re-enter the bloodstream...
This federal Project Grant award, totaling $495,057 and awarded on July 1, 2024 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research into the biochemical determinants of chemokine receptor signaling. The goal of the project is to biochemically define a new G protein-coupled receptor (GPCR) signaling pathway and investigate its role in T cell signaling, which is relevant to autoimmune skin and connective tissue diseases. The principal...
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This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under pathological inflammatory conditions. The research aims to elucidate how inflammation, particularly in the context of orthopedic periprosthetic...
This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
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This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $735,372 to Brigham & Women's Hospital Inc. to conduct research on T cell expression of inflammatory chemokine receptors in chronic autoimmune conditions. The research aims to identify transcription factors and cytokines that regulate the expression of key chemokine receptors, such as CCR2, CCR5, and CXCR6, which are involved in the migration of T cells to inflamed tissues in conditions like rheumatoid arthritis. The project will utilize CRISPR screens, cytokine stimulation assays, epigenetic analyses, spatial transcriptomics, and human synovial organoids to better understand the underlying mechanisms controlling this migratory program in T cells. The goal is to reveal dominant pathways that could lead to new strategies to therapeutically interfere with pathologic T cell migration in chronic autoimmune diseases. The award period runs from May 15, 2025, to February 28, 2030.

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