Project Grant RF1AG091479
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $4,055,366 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Southern California (USC). The grant, awarded on September 15, 2025, aims to investigate the impact of exposure to endocrine-disrupting persistent organic pollutants during the menopausal transition on cognition, brain activity, and Alzheimer's disease (AD) biomarkers. The project...
- The National Institute on Aging, under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $148,050 project grant to Northwestern University to investigate sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease. This 3-year project, starting on September 27, 2025 and completing on May 31, 2028, aims to: 1) utilize single-cell fixed RNA profiling to identify and evaluate cell-specific transcriptomic alterations in the Alzheimer's disease hypothalamus,...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,249,957 Project Grant under CFDA 93.866 (Aging Research) to Advantage Therapeutics, Inc. in Florida. The grant aims to perform IND-enabling studies on a small molecule that is disease-modifying, low-cost, and has a long safety record for the treatment of Alzheimer's disease. The proposed molecule is designed to reduce brain inflammation and restore phagocytosis, thereby improving the...
- This Project Grant award, valued at $2,129,396.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to develop and validate engineered adeno-associated viruses (AAVs) that can selectively knock down the follicle-stimulating hormone receptor (FSHR) in neurons within brain regions vulnerable to Alzheimer's disease. This research seeks to understand the role of FSH signaling in cognitive decline and Alzheimer's...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...
- The National Institute on Aging, under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $3,754,882 project grant to Mayo Clinic to investigate the effects of premenopausal bilateral oophorectomy (PBO) on imaging biomarkers of Alzheimer's disease and cerebrovascular disease in women. The project aims to enroll 400 women, including an African American cohort from Mayo Clinic Florida, to study how the abrupt disruption of ovarian hormones before natural menopause impacts the...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $167,940 project grant to The Children's Hospital Corporation (Boston Children's Hospital) to elucidate the neuronal mechanisms underlying cognitive resilience to Alzheimer's disease. The project, awarded on August 15, 2025, aims to (1) determine if the MEF2 transcription factors mediate survival of specific neuronal subtypes vulnerable to Alzheimer's pathology, (2) assess whether...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $412,500 Project Grant to the University of South Florida to investigate changes in the brain extracellular matrix during normal aging and in Alzheimer's disease. The 2-year grant, which runs from Jun 1, 2025 to May 31, 2027, aims to establish region-specific extracellular matrix composition in mouse brains, elucidate changes during normal aging, and characterize temporal and spatial...
- This $721,089.02 federal Project Grant award from the National Institute on Aging (part of the National Institutes of Health) under the Aging Research program (CFDA 93.866) will support research to delineate how epigenetic regulation of the ACVR1C gene contributes to age- and Alzheimer's disease-related memory impairments in females and males. The goal is to determine if ACVR1C functions as a self-regulating mechanism underlying these cognitive declines, and if overriding ACVR1C impairment can...
The U.S. National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $2,329,970 Project Grant to the University of Florida to conduct research on "Evaluation of the Neuroimmune Mechanisms Influencing Therapeutic Targeting Potential of the LH/CG Receptor in the Menopausal and AD Brain". This 4-year project, running from September 1, 2025 to August 31, 2029, seeks to investigate the potential immune-regulating role of the LH/CG receptor complex in the central nervous system and its relevance for Alzheimer's disease pathogenesis in the context of menopause. The research aims to elucidate the cell-specific effects of this hormone-receptor complex on CNS function, neuroplasticity, and inflammatory processes through conditional deletion studies, as well as evaluate its ability to inhibit peripheral immune cell infiltration mechanisms that contribute to neuroinflammation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 8/27/25 |