Project Grant R03AG095801
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $299,428 Project Grant to WNT Scientific LLC to develop an innovative medical device to treat nonunion fractures in older adults. The device is a biodegradable, controlled-release material designed to promote fracture healing by stimulating angiogenesis (blood vessel formation), which is impaired in elderly patients due to chronic inflammation. The awarded project aims to commercialize this...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $166,488 Project Grant to the University of California, Davis to investigate the role of hypoxia-inducible factor-2a (HIF-2a) signaling in age-induced bone loss. The project aims to identify mechanisms underlying bone deterioration with aging and develop novel therapies to reverse age-related osteoporotic bone loss and improve fracture resistance. The project period runs from December...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
- The University of Oregon received a $886,403 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research program) on September 15, 2025. The award supports the development of a nanoparticle-based therapeutic to accelerate fracture healing in aging populations. The nanoparticles are designed to target fracture sites and deliver a Wnt/β-catenin pathway agonist, providing a dual benefit of targeted delivery and therapeutic modulation. Preliminary data indicates...
- The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's...
- The National Institute on Aging (NIA) awarded a $639,997 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Spaulding Rehabilitation Hospital Corporation in Massachusetts on May 15, 2025. The grant supports a research project titled "Mechano-Regulation of Circulating Extracellular Vesicle Cargoes to Enhance Knee Joint Health" with a planned completion date of March 31, 2030. The project aims to investigate how physiological exercise regulates molecular...
- The National Institute on Aging (NIA) awarded a $333,125 Project Grant under the Aging Research (CFDA 93.866) federal grant program to George Washington University. The grant, which runs from September 17, 2024 to August 31, 2025, will fund the development and validation of artificial intelligence algorithms to predict body composition and physical function in older adults using low-cost 3D optical body scanning technology. The research aims to provide accessible and scalable methods to assess...
- The University of Pittsburgh received a $801,268 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The objective of this 5-year award, with a start date of June 1, 2025, is to develop an effective evidence-based approach to providing value-based perioperative care in high-risk elderly surgical patients. The project aims to improve prediction and prevention of postoperative mortality, delirium, cognitive decline, and other...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $393,750 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to The Ohio State University on August 15, 2025. The grant supports research to determine if geriatric fracture patients have altered macrophage polarization and an imbalanced inflammatory response compared to young patients, which may contribute to impaired fracture healing in the elderly. The project aims to quantify differences in the fracture microenvironment between young and elderly patients in order to develop targeted interventions to improve fracture healing outcomes for the geriatric population. The research will be conducted at The Ohio State University and is expected to be completed by July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $393.8k | 8/6/25 |