This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences provides $195,896 to enhance an ongoing weight loss study with older adults living with obesity. The key products and services include: Developing an automated image analysis platform to measure muscle quantity, quality, and changes over the 12-month study period using computed tomography (CT) scans of participants. Utilizing the CT data to develop...
The National Institute on Aging awarded a $835,056 Project Grant (CFDA 93.866) to Trustees of Tufts College (Tufts University) to develop a multi-modal system of wearable biosensors and advanced analytics for continuous monitoring of mobility and cognitive function in an aging population. The project aims to create a flexible, breathable, and inconspicuous sensor system (Aim 1) that can provide real-time data on biophysical domains like gait, posture, and heart rate. Building on this sensor...
The National Institute on Aging (NIA) awarded a $529,650 Project Grant under the Aging Research program (CFDA 93.866) to The Scintillon Institute, a non-profit biomedical research organization in San Diego, CA. The project aims to develop a comprehensive thermal imaging-based platform called ENTICE to longitudinally record and analyze age-related changes in physical activity energy expenditure (PAEE) and other components of total energy expenditure in young, middle-aged, and old mice. The goal...
The National Institute on Aging (NIA) awarded a $955,432 Project Grant under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University to conduct research on the "Neural Mechanisms of Gait Disturbances as Individualized Digital Biomarker Trajectories in Preclinical Dementia." The project aims to leverage cutting-edge AI and computer vision tools to identify nuanced markers of cognitive decline mirrored in gait and hand movement patterns, which can serve as...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a research initiative led by Dr. Peter Abadir at Johns Hopkins University. The $198,976 award supports the development of an AI-driven system to assess physical and cognitive function in frail older adults, including those with Alzheimer's disease. The research aims to correlate these digital biosignals with molecular markers, enhancing understanding of frailty characteristics and...
The Washington University Office of Sponsored Research Services Division was awarded a $460,659 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop novel artificial intelligence (AI) models for integrating and interpreting multi-omics datasets related to exceptional longevity. The project aims to (1) develop unbiased and semi-guided graph neural network models to infer core signaling pathways associated with exceptional lifespan, and (2) create...
This $4,449,044 National Institute on Aging project grant will support the development of statistical models and biomarkers linking cognitive and physical decline to dementia and disability onset. Funded under the Aging Research program (CFDA 93.866), the University of Maryland, Baltimore will analyze data from over 11,000 older adults in eight cohorts. Researchers will test relationships between biomarkers of aging and longitudinal cognitive-physical decline as well as time to joint...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $596,250 to the University of California, San Diego (UCSD) to develop a smartphone-based hand grip strength (HGS) measurement solution. The goal is to create a digital dynamometer using the phone's vibration motor and sensors to assess physical frailty as a biomarker for predicting post-surgical complications in older adults undergoing elective cardiac procedures. The 3-year project aims to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,811,559 to the University of Massachusetts to conduct a study on using wearable devices and AI techniques to develop digital biomarkers for early detection of Alzheimer's disease. The key objectives are to: Deploy consumer wearables for sleep, heart rate, and activity monitoring in a cohort of older adults with elevated genetic risk for Alzheimer's to quantify device accuracy and develop...
The National Institute on Aging (NIA) awarded a $1,744,358 Project Grant (CFDA 93.866 - Aging Research) to the University of Maryland, Baltimore (UMB) to develop novel analytical methods to understand post-fracture recovery trajectories in older adults with Alzheimer's disease and related dementias (ADRD). The project aims to 1) identify unique patient characteristics leading to poor longitudinal recovery outcomes, 2) develop joint modeling approaches to uncover shared mechanisms and enable...