Project Grant R03AG094334
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $429,000 to The Regents of the University of Colorado (doing business as University of Colorado-Denver) on August 15, 2025, under the Aging Research program (CFDA 93.866). The project, "Gut Microbiota Dynamics, Exercise and Physical Function Among Older People with HIV," will be completed by July 31, 2026. The research aims to investigate the relationship between gut microbiota composition,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Miami a Project Grant totaling $109,652.00 under the Aging Research program (CFDA 93.866) on September 5, 2026, with a completion date of September 4, 2027. This award supports research investigating T cell senescence-driven immune dysfunction in aging and HIV-positive populations. The research project aims to elucidate the mechanisms by which senescent T cells—cells that have undergone stable cell...
- Federal Project Grant Award Summary Emory University received a $3.25 million Project Grant from the National Institute on Aging (CFDA 93.866: Aging Research) effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the role of indole and related metabolites produced by commensal microbiota in promoting mobility and healthspan during aging. The research project focuses on understanding how indole compounds, secreted by beneficial bacteria,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Colorado-Denver a Project Grant totaling $634,658 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion deadline of November 30, 2030. This research project investigates the interaction between systemic endothelial glycocalyx fragility and brain dysfunction in aged sepsis survivors. The research focuses on understanding how heparan sulfate (HS)...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $694,824 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 1, 2025, with completion scheduled for May 31, 2030. The research project, titled "Triangulating Mechanisms of Microbiome-Joint Crosstalk," investigates the interorgan communication between the gut microbiome and joints in osteoarthritis (OA) pathogenesis. The primary...
- Federal Project Grant Award Summary The University of Missouri System received a $676,608 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026, through December 31, 2030. This research initiative investigates the role of the gut-brain axis in Alzheimer's disease (AD) mitigation through an integrated translational study combining human clinical research with preclinical animal experiments. The project employs advanced 7-Tesla magnetic...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $629,562 Project Grant on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of mechanical stiffening of the intestine in age-related decline of intestinal health and function. The research project, scheduled for completion on July 31, 2030, will deliver scientific research and analysis examining how aging-associated mechanical changes in intestinal...
- Federal Project Grant Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded $393,750 to the University of California, Los Angeles on September 22, 2025, to conduct a prospective cohort study evaluating the impact of gastroesophageal cancer (GEC) treatments on physical function in older adults aged 60 years and above. The research project, with completion scheduled for August 31, 2027, will deliver scientific evidence through serial geriatric...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $388,750 to The Washington University on September 19, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research investigating the mechanisms that drive host-associated microbial community dynamics. The project, which runs through July 31, 2030, focuses on understanding how environmental and host physiological factors interact to shape gut...
The National Institute on Aging (NIA) awarded the University of Colorado-Denver a $156,000 Project Grant under the Aging Research program (CFDA 93.866) for the period April 1, 2026 through March 31, 2028. The project, titled "Gut Check: The Impact of Gut Bacteria on Physical Function in Older Adults with and without HIV," supports biomedical research directed toward understanding the relationship between gut microbiome composition and physical function decline in aging populations. The research specifically investigates how alterations in gut microbial communities (dysbiosis) contribute to frailty and reduced physical function in both HIV-positive and HIV-negative older adults, with the objective of identifying specific bacterial genera associated with functional outcomes and vulnerability to age-related decline. The research project builds upon preliminary findings from the MACS/WIHS Combined Cohort Study (MWCCS) demonstrating differential associations between gut microbiome composition and frailty outcomes by HIV serostatus and age. This two-year initiative will generate scientific knowledge regarding mechanisms linking gut bacteria to physical function and aging outcomes, potentially informing future therapeutic interventions targeting the microbiome to maintain functional capacity and support successful aging in diverse older adult populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.0k | 3/26/26 |