Project Grant R01AG082255

Award Date 9/30/24
Completion Date 6/30/29
Dollars Obligated $767K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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This three-year, $4.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in Alzheimer's disease pathogenesis and neuroinflammatory signaling by microglia. Researchers will generate mouse models lacking BIN1 specifically in microglia to study effects on amyloid plaque burden, tau pathology...
This three-year, $4,349,236 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in modulating Alzheimer's disease tau neuropathology in vivo. Researchers will generate cell-type specific inducible BIN1 knockout mice to characterize tau pathogenesis using longitudinal MRI and neuropathology. They will test...
This $466,531 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by Texas A&M AgriLife Research to investigate the role of the BIN1 protein in oligodendrocytes and its impact on axon integrity. The research aims to provide new insights into how the BIN1 genetic risk factor may relate to the onset and progression of late-onset Alzheimer's disease. The project will utilize oligodendrocyte-specific BIN1 knockout mice and a...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,288,327 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The goal is to better understand the early trajectory of MCI and AD by integrating polygenic risk scores with multi-omic characterization of patient-derived induced neurons. This will...
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...
The $433,824 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research into transcriptomic control of dentate granule cell maturation and hyperexcitability in the APOE4 Alzheimer's disease model. The J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, will conduct electrophysiological, transcriptomic, and morphological analyses of adult-born dentate granule cells to understand how APOE4...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports the development and characterization of brain organoid models to study the mechanisms underlying Alzheimer's disease (AD) onset and progression. The $2,319,456 award to the University of California, San Diego will be used to create isogenic induced pluripotent stem cell (iPSC) lines with various AD-related mutations, as well as control lines, and develop brain organoids...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $767,112 in funding to the University of California, San Diego to study the role of the BIN1 gene in Alzheimer's disease pathogenesis. The central goal of the project is to use in vitro and in vivo models to elucidate how genetic variations in a microglial-specific enhancer region upstream of BIN1 contribute to tauopathy, a hallmark of Alzheimer's disease. The researchers will employ innovative techniques such as CRISPR/Cas9-mediated enhancer deletions, human induced pluripotent stem cell models, cocultures, and a xenotransplantation mouse model to investigate the downstream pathways and mediators of microglial BIN1 and its potential impact on neurodegeneration. This 5-year project aims to provide new insights into the cell-type specific effects of non-coding genetic variants associated with Alzheimer's disease risk, with the long-term goal of identifying novel therapeutic targets and pathways for early intervention and disease prevention.

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