Project Grant R03AG088612

Award Date 9/1/24
Completion Date 6/30/26
Dollars Obligated $310K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15222, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $129,659 to The Johns Hopkins University to conduct a longitudinal study examining the relationship between physical activity, sleep, brain network connectivity/microstructure, and cognitive resilience in aging and preclinical Alzheimer's disease. The research aims to identify modifiable lifestyle factors and neuroimaging biomarkers that may enhance cognitive resilience and help elucidate the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
This Project Grant award of $835,056, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports the development of a multi-modal system of wearable biosensors and predictive analytics to enable continuous monitoring of mobility and cognitive function in older adults. The primary goals are to: Develop a system of flexible, breathable, and inconspicuous eutectogel sensor patches that can provide real-time monitoring of biophysical domains like gait, posture, heart rate,...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is funding a research project to investigate the neural mechanisms underlying cognitive contributions to walking as an early marker for risk of Alzheimer's disease and related dementias (ADRD). The total award amount is $2,030,488 and the project period runs from Sep 17, 2024 to May 31, 2029. The research aims to: 1) Investigate gait deficits during tasks requiring...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $367,056 to The University of Iowa to investigate the use of low-cost, commercially available activity trackers and computer vision technology for remote monitoring and holistic assessment of Parkinson's disease symptoms. The research aims to: 1) develop a classifier to predict Parkinson's disease diagnosis and cognitive impairment using in-home motor and speech assessments, and 2) improve...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
The National Institute on Aging (NIA) awarded a $730,089 Project Grant under CFDA 93.866 (Aging Research) to Washington University in St. Louis. The purpose of this 5-year study, titled "LIFE-SPACE, ISOLATION, AND FUNCTIONAL EXPOSOME STUDY IN PRECLINICAL ALZHEIMER'S DISEASE AND COGNITIVE ENVIRONMENTS (LIFESPACE)", is to examine the use of digital markers from everyday activities, such as driving and physical activity, to identify biological indicators of preclinical Alzheimer's disease...
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This Project Grant award of $309,550.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study to develop and apply a novel "physical activity (PA) complexity" metric using accelerometer data to explore associations between PA patterns, cognitive function, and risk of Alzheimer's disease and related dementias (ADRD) in an older adult population.

The key objectives are to: (1) examine the links between PA complexity, cognitive performance, and risk of mild cognitive impairment and Alzheimer's disease; (2) determine if low PA complexity relates to biomarker classifications and white matter changes; and (3) assess whether low PA complexity is associated with brain atrophy. This research aims to yield insights into the underlying mechanisms connecting motor function to brain aging and provide new directions for interventions to prevent or delay ADRD onset. The project will be conducted by the University of Pittsburgh over the period of Sep 1, 2024 to Jun 30, 2026.

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