The National Institute on Aging (NIA) awarded a $630,496 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA. The grant, which runs from June 1, 2025 to March 31, 2030, supports research into the proteostasis, neuroinflammation, and neurodegeneration mechanisms underlying frontotemporal dementia (FTD) caused by GRN haploinsufficiency. Key objectives include defining the alterations...
This $4,893,884 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research federal grant program (CFDA 93.866). The University of Florida will lead a collaborative effort to understand the role of central and peripheral immune crosstalk in frontotemporal dementia with progranulin mutations (FTD-GRN), an Alzheimer's disease-related dementia. The University of Florida and sub-awardees the J. David Gladstone...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award, valued at $224,140, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a renowned academic medical center. The purpose of this 2-year grant, running from September 1, 2024 to August 31, 2026, is to elucidate the relationship between cortical hyperactivity, the progression of frontotemporal dementia (FTD) pathology, and associated...
This federal Project Grant award, with an ID of RF1NS142354, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the impact of progranulin protein species on the accumulation of TDP-43, a key protein implicated in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant age-associated TDP-43 encephalopathy. The $1,275,512 award, with a project period from June 1, 2025 to May 31, 2027, will be implemented by...
This three-year, $5.782 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into single-cell characterization of frontotemporal lobar degeneration caused by mutations in the progranulin gene. The University of California, San Francisco will map the transcriptome and gene regulatory networks that define glial pathology and neuronal vulnerability in the frontal cortex and thalamus of progranulin-deficient...
The National Institute on Aging (NIA) awarded a $799,700 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University College London (UCL) to conduct a "Systems Genetics Analysis of Resilience to Tauopathy in ADRD." The primary objective is to combine a well-characterized mouse model of tauopathy with the genetically diverse BXD mouse population to establish the FTD-BXD mouse model. This will allow the researchers to identify genetic factors underlying...
This $1,076,760 five-year Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support research by the Vlaams Instituut Voor Biotechnologie (VIB) in Gent, Belgium to develop a humanized mouse model for frontotemporal lobar degeneration (FTLD) with TAR DNA-binding protein 43 (TDP-43) pathology. The key objectives are to: 1) Generate a humanized FTLD-TDP model by transplanting patient-derived GRN-deficient microglia into the brains of mice overexpressing the...
This federal Project Grant award, funded by the National Institute on Aging under CFDA 93.866 (Aging Research), provides $104,164 to Emory University to explore the role of TMEM106B, a gene linked to neurodegenerative disorders. Specifically, the project aims to: 1) determine the interaction between TMEM106B and the C9ORF72 gene, which is associated with frontotemporal dementia and amyotrophic lateral sclerosis, and 2) investigate the toxicity of TMEM106B protein aggregates and their impact on...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,138,538 to Mayo Clinic Jacksonville to conduct research focused on understanding the diverse mechanisms underlying frontotemporal lobar degeneration (FTLD) and related neurodegenerative disorders. The research aims to explore the molecular underpinnings of TDP-43 localization...