Project Grant R03AG083556

Award Date 9/15/24
Completion Date 8/31/26
Dollars Obligated $315K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43210, USA
Similar Awards
This Project Grant award from the National Institute of Nursing Research (NINR), under CFDA 93.361 Nursing Research, provides $417,702 to Oregon Health & Science University (OHSU) to study the relationship between physical frailty, symptom monitoring and management behaviors, and outcomes in adults with heart failure. The research project aims to: 1) quantify the associations among physical frailty, symptom monitoring and management behaviors, and outcomes in heart failure patients; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University totaling $501,631 will support a study to evaluate how proteomic signatures of frailty respond to a physical rehabilitation intervention in older adults with heart failure with preserved ejection fraction (HFpEF). The key objectives are to: 1) Identify how the circulating proteome changes with physical rehabilitation in the REHAB-HF trial and how these changes relate to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop effective, scalable tools and interventions to reduce postoperative mortality, delirium, cognitive decline, and other adverse outcomes in vulnerable elderly surgical patients. The 5-year, $801,268 award to the University of Pittsburgh will fund research to create reliable preoperative risk prediction models and enable proactive multimodal perioperative interventions, including...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $339,038 to the University of Pittsburgh to study the prevalence and impact of frailty in older adults with polymyalgia rheumatica (PMR). The award period runs from Sep 15, 2024 to Aug 31, 2026. The key objectives are to: 1) Determine the association of frailty with glucocorticoid duration and prescription analgesic use in older adults with PMR, and 2) Examine the association of physical...
This Project Grant award of $126,099.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate molecular phenotypes of frailty in lung transplantation. The principal investigator, an Associate Professor and lung transplant pulmonologist, will leverage existing research programs and collaborations to examine the heterogeneous pathobiology of pre- and...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) in the amount of $448,270 supports research on the role of alveolar type II (ATII) cell senescence in the pathogenesis of influenza in aging populations. The Ohio State University will conduct this 2-year research project aimed at defining the effects of aging, influenza virus infection, and a potential therapeutic treatment (CDP-choline) on ATII cell function, energy metabolism, and...
The National Institute on Aging (NIA) awarded a $689,170 Project Grant (CFDA 93.866) to Adaptive Testing Technologies Inc. to develop and validate a Computerized Adaptive Test of Fatigability (CAT-F) for hospitalized older adults. The research aims to apply multidimensional item response theory to create an adaptive test that can precisely measure fatigability - the level of fatigue experienced at a given activity level - in order to better identify patients at risk of functional decline and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,512 to the University of Florida to conduct research on the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and muscle weakness. The 16-month project will use novel genetic mouse models to investigate whether elevated kynurenine levels and increased AhR activity in skeletal muscle are mechanistic drivers of the decline in...
This $834,094 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to advance research on post-stroke cognitive impairment and dementia (PSCID). The funding will support a multi-year effort leveraging a national stroke registry and Medicare data to determine the incidence and prevalence of PSCID, identify associated risk factors, and explore potential pharmacological prevention strategies. Key aspects of the research include a patient-centered approach,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $115,411.00 to evaluate dynamic changes in aging-related clinical decline among older survivors with early-stage non-small cell lung cancer. The award to Weill Medical College of Cornell University aims to identify multilevel determinants, including social determinants of health, associated with disparities in clinical decline trajectories. This longitudinal study of over 89,000 lung...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will validate questionnaire-based methods for assessing frailty in older adults who have survived critical illness. The 2-year, $315,000 award to The Ohio State University aims to determine the validity and reliability of patient and surrogate responses on questionnaire-based frailty assessments compared to performance-based assessments. This research is intended to facilitate the study of trajectories, risk factors, and mechanisms of critical illness-associated frailty, which is an emerging public health issue driven by the growing number of critical illness survivors and the aging U.S. population. The findings from this innovative study are expected to improve long-term health outcomes for older adults who survive critical illness.

Generated 8/5/25, 5:43 AM